A broad-spectrum aminoglycoside antibiotic
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Sisomicin

Item No. 21046

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
O-3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-α-D-glycero-hex-4-enopyranosyl-(1→4)]-2-deoxy-D-streptamine
CAS Number
32385-11-8
Synonyms
  • Antibiotic 6640
  • SCH 13475
Molecular Formula
C19H37N5O7
Formula Weight
447.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMF: 30 mg/mLDMSO: 25 mg/mLDMSO: 30 mg/mlEthanol: 25 mg/mLEthanol: 25 mg/mlPBS (pH 7.2): 5 mg/mLPBS (pH 7.2): 5 mg/ml
SMILES
N[C@H]1[C@](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@@]3([H])OC[C@](C)(O)[C@H](NC)[C@H]3O)[C@H]2O)([H])OC(CN)=CC1
InChi Code
InChI=1S/C19H37N5O7/c1-19(27)7-28-18(13(26)16(19)24-2)31-15-11(23)5-10(22)14(12(15)25)30-17-9(21)4-3-8(6-20)29-17/h3,9-18,24-27H,4-7,20-23H2,1-2H3/t9-,10+,11-,12+,13-,14-,15+,16-,17-,18-,19+/m1/s1
InChi Key
URWAJWIAIPFPJE-YFMIWBNJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    Sisomicin is a broad-spectrum aminoglycoside antibiotic originally isolated from M. inyoensis.1 It is active against Gram-positive and Gram-negative bacteria including B. subtilis, S. aureus, E. coli, and P. aeruginosa among others (MICs = 0.01-0.75 µg/ml) but is less active against P. multocida and V. coli (MICs = 7.5 and 2.4 µg/ml, respectively). Sisomicin is protective against Gram-positive and Gram-negative bacterial infections in mice with 50% protective dose (PD50s) values ranging from 0.5 to 6 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Weinstein, M.J., Marquez, J.A., Testa, R.T., et al. Antibiotic 6640, a new Micromonospora-produced aminoglycoside antibiotic. J. Antibiot. (Tokyo) 23(11), 551-554 (1970).