A synthetic analog of BH4
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Product Categories

Product Type

Biochemicals

Research Area

Cell Biology
Cell Signaling
Nitric Oxide Signaling

6,7-dimethyl-5,6,7,8-Tetrahydropterin (hydrochloride)

Item No. 21050

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-amino-5,6,7,8-tetrahydro-6,7-dimethyl-4(3H)-pteridinone, monohydrochloride
CAS Number
945-43-7
Synonyms
  • DMPH4
  • NSC 87950
Molecular Formula
C8H13N5O • HCl
Formula Weight
231.7
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 1 mg/ml
λmax
218, 266 nm
SMILES
NC(NC1=C2NC(C)C(C)N1)=NC2=O.Cl
InChi Code
InChI=1S/C8H13N5O.ClH/c1-3-4(2)11-6-5(10-3)7(14)13-8(9)12-6;/h3-4,10H,1-2H3,(H4,9,11,12,13,14);1H
InChi Key
GIHYTRGUZVYCQX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

    $20

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    50 mg

    $37

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    100 mg

    $69

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    250 mg

    $159

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    Product Description

    6,7-dimethyl-5,6,7,8-Tetrahydropterin is a synthetic analog of tetrahydro-L-biopterin (BH4; Item No. 81880), a required cofactor for all NOS isoforms, phenylalanine, tyrosine, and tryptophan hydroxylases, and other enzymes.1,2,3,4,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mayer, B., and Werner, E.R. In search of a function for tetrahydrobiopterin in the biosynthesis of nitric oxide. N.-S. Arch. Pharmacol. 351(5), 453-463 (1995).

    2. Chaube, R., and Joy, K.P. Effects of ovariectomy and oestradiol-17beta replacement on brain tyrosine hydroxylase in the catfish Heteropneustes fossilis: changes in in vivo activity and kinetic parameters. J. Endocrinol. 175(2), 329-342 (2002).

    3. Jennings, I., and Cotton, R. Structural similarities among enzyme pterin binding sites as demonstrated by a monoclonal anti-idiotypic antibody. The Journal of Biological Chemisty 265(4), 1885-1889 (1990).

    4. Suckling, C.J., Gibson, C.L., Huggan, J.K., et al. 6-Acetyl-7,7-dimethyl-5,6,7,8-tetrahydropterin is an activator of nitric oxide synthases. Bioorg. Med. Chem. Lett. 5(1), 1563-1566 (2008).

    5. Volner, A., Zoidakis, J., and Abu-Omar, M.M. Order of substrate binding in bacterial phenylalanine hydroxylase and its mechanistic implication for pterin-dependent oxygenases. J. Biol. Inorg. Chem. 8(1-2), 121-128 (2002).