A fatty acid amide
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Elaidamide

Item No. 21079

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9E-octadecenamide
CAS Number
4303-70-2
Synonyms
  • Elaidic Acid amide
  • (E)-9,10-Octadecenamide
Molecular Formula
C18H35NO
Formula Weight
281.5
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2mg/mLDMF:PBS (pH 7.2) (1:1): 0.5mg/mL
SMILES
CCCCCCCC/C=C/CCCCCCCC(N)=O
InChi Code
InChI=1S/C18H35NO/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H2,19,20)/b10-9+
InChi Key
FATBGEAMYMYZAF-MDZDMXLPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $41

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    50 mg

    $178

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    100 mg

    $312

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    Product Description

    Elaidamide is a fatty acid amide that has been found in the cerebrospinal fluid of sleep-deprived cats.1 It inhibits rat microsomal epoxide hydrolase (mEH; Ki = 70 nM).2 Elaidamide also inhibits porcine pancreatic and human synovial phospholipase A2 (PLA2).3 In vivo, elaidamide (10 mg/animal) induces physiological sleep in rats.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cravatt, B.F., Prospero-Garcia, O., Siuzdak, G., et al. Chemical characterization of a family of brain lipids that induce sleep. Science 268(5216), 1506-1509 (1995).

    2. Morisseau, C., Newman, J.W., Dowdy, D.L., et al. Inhibition of microsomal epoxide hydrolases by ureas, amides, and amines. Chem. Res. Toxicol. 14(4), 409-415 (2001).

    3. Jain, M.K., Ghomashchi, F., Yu, B.Z., et al. Fatty acid amides: Scooting mode-based discovery of tight-binding competitive inhibitors of secreted phospholipases A2. J. Med. Chem. 35(19), 3584-3586 (1992).