Fetal calf serum modified with potassium cyanate
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Carbamylated Fetal Calf Serum

Item No. 21097

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Ca-FCS
  • Carbamylated FCS
Source
Fetal calf serum modified with potassium cyanate
Formulation (Request formulation change)
A lyophilized powder
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $436

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    Cayman Chemical
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    Product Description

    Citrullination and carbamylation are two post-translational modifications that result in the generation of citrulline and homocitrulline, two highly related, non-standard amino acids. While citrullination of arginine is catalyzed by peptidylarginine deiminases (PADs), homocitrulline results from the non-enzymic reaction of cyanate with lysine. Carbamylation occurs at low levels in healthy individuals, but at higher levels in several clinical conditions such as atherosclerosis, kidney disease, and inflammation.1,2,3 Carbamylation can lead to changes in protein function, cellular function, and generation of an immune response to homocitrulline containing proteins.1,2,3 This product contains carbamylated fetal calf serum.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shi, J., van Veelen, P.A., Mahler, M., et al. Carbamylation and antibodies against carbamylated proteins in autoimmunity and other pathologies. Autoimmun. Rev. 13(3), 225-230 (2014).

    2. Pruijn, G.J.M. Citrullination and carbamylation in the pathophysiology of rheumatoid arthritis. Front. Immunol. 6, 192 (2015).

    3. Mastrangelo, A., Colasanti, T., Barbati, C., et al. The role of posttranslational protein modifications in rheumatological diseases: Focus on rheumatoid arthritis. J. Immunol. Res. 712490 (2015).