An inhibitor of hedgehog acyltransferase
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RU-SKI 201 (hydrochloride)

Item No. 21101

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[6,7-dihydro-4-(6-methyl-2-pyridinyl)thieno[3,2-c]pyridin-5(4H)-yl]-2-[(2-methylbutyl)amino]-ethanone, dihydrochloride
CAS Number
2320262-09-5
Molecular Formula
C20H27N3OS • 2HCl
Formula Weight
430.4
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2) (1:3): 0.25 mg/ml
λmax
203, 266 nm
SMILES
CCC(C)CNCC(N1CCC2=C(C=CS2)C1C3=NC(C)=CC=C3)=O.Cl.Cl
InChi Code
InChI=1S/C20H27N3OS.2ClH/c1-4-14(2)12-21-13-19(24)23-10-8-18-16(9-11-25-18)20(23)17-7-5-6-15(3)22-17;;/h5-7,9,11,14,20-21H,4,8,10,12-13H2,1-3H3;2*1H
InChi Key
TUDOZEOETHEGCR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    Product Description

    RU-SKI 201 is an inhibitor of hedgehog acyltransferase (Hhat; IC50 = 0.2 μM for recombinant enzyme).1 It inhibits palmitoylation of sonic hedgehog (Shh) in Shh-overexpressing HEK293 cells with a tagging IC50 (TC50) value of 0.87 μM. RU-SKI 201 inhibits hedgehog (Hh) signaling in H520, PANC-1, and MCF-7 cancer cells co-cultured with Shh-Light2 cells (IC50s = 4.8, 7.8, and 8.5 μM, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rodgers, U.R., Lanyon-Hogg, T., Masumoto, N., et al. Characterization of hedgehog acyltransferase inhibitors identifies a small molecule probe for hedgehog signaling by cancer cells. ACS Chem. Biol. 11(12), 3256-3262 (2016).