An inhibitor of Nrf2
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ML-385

Item No. 21114

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[4-[2,3-dihydro-1-(2-methylbenzoyl)-1H-indol-5-yl]-5-methyl-2-thiazolyl]-1,3-benzodioxole-5-acetamide
CAS Number
846557-71-9
Molecular Formula
C29H25N3O4S
Formula Weight
511.6
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH 7.2)(1:3): 0.25 mg/mlDMSO: 25 mg/ml
λmax
288 nm
SMILES
O=C(NC1=NC(C2=CC=C(N(C(C3=CC=CC=C3C)=O)CC4)C4=C2)=C(C)S1)CC5=CC(OCO6)=C6C=C5
InChi Code
InChI=1S/C29H25N3O4S/c1-17-5-3-4-6-22(17)28(34)32-12-11-20-15-21(8-9-23(20)32)27-18(2)37-29(31-27)30-26(33)14-19-7-10-24-25(13-19)36-16-35-24/h3-10,13,15H,11-12,14,16H2,1-2H3,(H,30,31,33)
InChi Key
LINHYWKZVCNAMQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $103

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    10 mg

    $194

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    25 mg

    $427

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    Cayman Chemical
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    Product Description

    ML-385 is an inhibitor of nuclear factor erythroid 2-related factor 2 (Nrf2; IC50 = 1.9 µM) that blocks downstream target gene expression.1 It substantially enhances cytotoxicity in non-small cell lung cancer (NSCLC) cells treated with platinum-based drugs.1 ML-385 shows specificity and selectivity for NSCLC cells with KEAP1 mutation, which leads to gain of Nrf2 function.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Singh, A., Venkannagari, S., Oh, K.H., et al. Small molecule inhibitor of NRF2 selectively intervenes therapeutic resistance in KEAP1-deficient NSCLC tumors. ACS Chem Biol. 11(11), 3214-3225 (2016).