An inhibitor of BACE1 and BACE2
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Verubecestat

Item No. 21115

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[3-[(5R)-3-amino-5,6-dihydro-2,5-dimethyl-1,1-dioxido-2H-1,2,4-thiadiazin-5-yl]-4-fluorophenyl]-5-fluoro-2-pyridinecarboxamide
CAS Number
1286770-55-5
Synonyms
  • MK-8931
Molecular Formula
C17H17F2N5O3S
Formula Weight
409.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 35 mg/ml
λmax
278 nm
SMILES
FC1=CN=C(C(NC2=CC([C@]3(C)CS(N(C)C(N)=N3)(=O)=O)=C(F)C=C2)=O)C=C1
InChi Code
InChI=1S/C17H17F2N5O3S/c1-17(9-28(26,27)24(2)16(20)23-17)12-7-11(4-5-13(12)19)22-15(25)14-6-3-10(18)8-21-14/h3-8H,9H2,1-2H3,(H2,20,23)(H,22,25)/t17-/m0/s1
InChi Key
YHYKUSGACIYRML-KRWDZBQOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $32

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    5 mg

    $109

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    10 mg

    $156

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    25 mg

    $271

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    Product Description

    Verubecestat is an inhibitor of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) and BACE2 (Kis = 2.2 and 0.38 nM, respectively).1 It has a high selectivity for BACE1 and BACE2 over closely related aspartyl proteases, including cathepsin D.1 Formulations containing verubecestat profoundly lower levels of β-amyloid proteins in brain and cerebrospinal fluid (CSF) in rats and nonhuman primates and in CSF in humans.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Scott, J.D., Li, S.W., Brunskill, A.P.J., et al. Discovery of the 3-Imino-1,2,4-thiadiazinane 1,1-dioxide derivative verubecestat (MK-8931)- a β-site amyloid precursor protein cleaving enzyme 1 inhibitor for the treatment of Alzheimer’s disease. J. Med. Chem. 59(23), 10435-10450 (2016).

    2. Kennedy, M.E., Stamford, A.W., Chen, X., et al. The BACE1 inhibitor verubecestat (MK-8931) reduces CNS β-amyloid in animal models and in Alzheimer’s disease patients. Sci. Transl. Med. 8(363), 363ra150 (2016).