An LXR modulator
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LXR-623

Item No. 21117

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[(2-chloro-4-fluorophenyl)methyl]-3-(4-fluorophenyl)-7-(trifluoromethyl)-2H-indazole
CAS Number
875787-07-8
Synonyms
  • WAY-252623
Molecular Formula
C21H12ClF5N2
Formula Weight
422.8
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mLDMSO: 30 mg/mLEthanol: 30 mg/mLEthanol:PBS (pH 7.2)(1:2): 0.3 mg/mL
λmax
209, 318 nm
SMILES
FC(C=C1)=CC=C1C2=C3C(C(C(F)(F)F)=CC=C3)=NN2CC4=CC=C(F)C=C4Cl
InChi Code
InChI=1S/C21H12ClF5N2/c22-18-10-15(24)9-6-13(18)11-29-20(12-4-7-14(23)8-5-12)16-2-1-3-17(19(16)28-29)21(25,26)27/h1-10H,11H2
InChi Key
KYWWJENKIMRJBI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $110

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    10 mg

    $203

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    Product Description

    LXR-623 is a liver X receptor (LXR) modulator that acts as a partial agonist at LXRα and a full agonist at LXRβ (IC50s = 179 and 24 nM, respectively).1,2 It is orally bioavailable and readily passes the blood-brain barrier.1,2,3 LXR-623 is anti-atherogenic in animal models of atherosclerosis, showing synergistic effects when combined with simvastatin (Item Nos. 10010344 | 10010345).1,4,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. DiBlasio-Smith, E., Arai, M., Quinet, E.M., et al. Discovery and implementation of transcriptional biomarkers of synthetic LXR agonists in peripheral blood cells. J. Transl. Med. 6, 59 (2008).

    2. Quinet, E.M., Basso, M.D., Halpern, A.R., et al. LXR ligand lowers LDL cholesterol in primates, is lipid neutral in hamster, and reduces atherosclerosis in mouse. J. Lipid. Res. 50(12), 2358-2370 (2009).

    3. Villa, G.R., Hulce, J.J., Zanca, C., et al. An LXR-cholesterol axis creates a metabolic co-dependency for brain cancers. Cancer Cell. 30(5), 683-693 (2016).

    4. Giannarelli, C., Cimmino, G., Connolly, T.M., et al. Synergistic effect of liver X receptor activation and simvastatin on plaque regression and stabilization: An magnetic resonance imaging study in a model of advanced atherosclerosis. Eur. Heart J. 33(2), 264-273 (2012).