An inhibitor of ADP/ATP translocases
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Carboxyatractyloside (potassium salt)

Item No. 21120

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2β,15α)-15-hydroxy-2-[[2-O-(3-methyl-1-oxobutyl)-3,4-di-O-sulfo-α-D-glucopyranosyl]oxy]-kaur-16-ene-18,19-dioic acid
CAS Number
35988-42-2
Molecular Formula
C31H44O18S2 • 2K
Formula Weight
847.0
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
Water: 10 mg/ml
SMILES
C=C([C@H](CC1)C2)[C@H](O)[C@@]32CC[C@]4([H])C(C([O-])=O)(C([O-])=O)C[C@@H](O[C@@H]5[C@@H]([C@H]([C@@H]([C@@H](CO)O5)OS(=O)(O)=O)OS(=O)(O)=O)OC(CC(C)C)=O)C[C@@]4(C)[C@@]31[H].[K+].[K+]
InChi Code
InChI=1S/C31H46O18S2.2K/c1-14(2)9-21(33)47-24-23(49-51(42,43)44)22(48-50(39,40)41)18(13-32)46-26(24)45-17-11-29(4)19-6-5-16-10-30(19,25(34)15(16)3)8-7-20(29)31(12-17,27(35)36)28(37)38;;/h14,16-20,22-26,32,34H,3,5-13H2,1-2,4H3,(H,35,36)(H,37,38)(H,39,40,41)(H,42,43,44);;/q;2*+1/p-2/t16-,17+,18-,19+,20+,22-,23+,24-,25+,26+,29+,30-;;/m1../s1
InChi Key
FPJGZZYAZUKPAD-AOBWAYCDSA-L
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    1 mg

    $43

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    5 mg

    $108

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    10 mg

    $194

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    25 mg

    $429

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    Product Description

    Carboxyatractyloside is a natural heteroglucoside produced in some plants, including A. gummifera.1 Carboxyatractyloside prevents mitochondrial ATP synthesis by inhibiting ADP/ATP translocases, which are responsible for the exchange of adenine di- and triphosphates across the inner mitochondrial membrane.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Dahout-Gonzalez, C., Hury, H., Trézéguet, V., et al. Molecular, functional, and pathological aspects of the mitochondrial ADP/ATP carrier. Physiology (Bethesda) 21, 242-249 (2006).

    2. Klingenberg, M. The ADP and ATP transport in mitochondria and its carrier. Biochim. Biophys. Acta 1778(10), 1978-2021 (2008).