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Item No. 21124

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all-cis-4,7,10,13,16-Docosapentaenoic acid (all-cis-4,7,10,13,16-DPA) methyl ester is a more lipid-soluble form of the free acid (Item No. 10008335). all-cis-4,7,10,13,16-DPA, also known as osbond acid, is an isomer of DPA (Item No. 90165) an ω-3, 22-carbon fatty acid found in fish oils. It is an ω-6 fatty acid formed by the elongation and desaturation of arachidonic acid (Item No. 90010). Levels of all-cis-4,7,10,13,16-DPA fatty acid may be diminished during fatty acid desaturase syndrome and this may affect development.1 Upregulated expression of hepatic elongation of very long fatty acids protein 6 and increased levels of very long chain fatty acids, including all-cis-4,7,10,13,16-DPA, are characteristic of nonalcoholic steatohepatitis, a preneoplastic condition of hepatocellular carcinoma.2
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1. Maternal fatty acids in pregnancy, FADS polymorphisms, and child intelligence quotient at 8 y of age. Am. J. Clin. Nutr. 98(6), 1575-1582 (2013).
2. Proteomic and lipidomic signatures of lipid metabolism in NASH-