An Mcl-1 inhibitor
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S63845

Item No. 21131

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
α(R)-[[(5S)-5-[3-chloro-2-methyl-4-[2-(4-methyl-1-piperazinyl)ethoxy]phenyl]-6-(5-fluoro-2-furanyl)thieno[2,3-d]pyrimidin-4-yl]oxy]-2-[[1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl]methoxy]-benzenepropanoic acid
CAS Number
1799633-27-4
Molecular Formula
C39H37ClF4N6O6S
Formula Weight
829.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH7.2) (1:7): 0.1 mg/ml
λmax
324 nm
SMILES
OC([C@@H](CC1=CC=CC=C1OCC2=CC=NN2CC(F)(F)F)OC3=NC=NC4=C3C(C5=C(C)C(Cl)=C(OCCN6CCN(C)CC6)C=C5)=C(C7=CC=C(F)O7)S4)=O
InChi Code
InChI=1S/C39H37ClF4N6O6S/c1-23-26(7-8-28(34(23)40)53-18-17-49-15-13-48(2)14-16-49)32-33-36(45-22-46-37(33)57-35(32)29-9-10-31(41)55-29)56-30(38(51)52)19-24-5-3-4-6-27(24)54-20-25-11-12-47-50(25)21-39(42,43)44/h3-12,22,30H,13-21H2,1-2H3,(H,51,52)/t30-
InChi Key
ZFBHXVOCZBPADE-SSEXGKCCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

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    5 mg

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    Cayman Chemical
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    Product Description

    S63845 is an inhibitor of myeloid cell leukemia 1 (Mcl-1; Ki = 0.19 nM), a pro-survival protein that is overexpressed in many cancers.1 It induces cell death in multiple myeloma, leukemia, and lymphoma cell lines (IC50s = <0.1-282 nM) via mitochondrial apoptosis. S63845 acts synergistically with trametinib (Item No. 16292), lapatinib (Item No. 11493), PLX4032 (Item No. 10618), and erlotinib (Item No. 10483) to reduce proliferation of SK-MEL-2, BT474, A2058, and PC9 cells, respectively. S63845 (6.25-25 mg/kg) reduces tumor volume in an MV4-11 acute myeloid leukemia mouse xenograft model in a dose-dependent manner.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kotschy, A., Szlavik, Z., Murray, J., et al. The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models. Nature 538(7626), 477-482 (2016).