An inhibitor of truncated APC
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TASIN-1

Item No. 21155

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1'-[(4-methoxyphenyl)sulfonyl]-4-methyl-1,4'-bipiperidine
CAS Number
792927-06-1
Molecular Formula
C18H28N2O3S
Formula Weight
352.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH 7.2) (1:4): 0.2 mg/mlDMSO: 15 mg/mlEthanol: 25 mg/ml
λmax
241 nm
SMILES
CC1CCN(C2CCN(S(C3=CC=C(OC)C=C3)(=O)=O)CC2)CC1
InChi Code
InChI=1S/C18H28N2O3S/c1-15-7-11-19(12-8-15)16-9-13-20(14-10-16)24(21,22)18-5-3-17(23-2)4-6-18/h3-6,15-16H,7-14H2,1-2H3
InChi Key
XCBHYDPDIJQQGM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $143

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    1 mg

    $255

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    Cayman Chemical
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    Product Description

    TASIN-1 is a small molecule inhibitor that specifically kills cells with adenomatous polyposis coli (APC) truncations (IC50 = 70 nM) but spares cells with wild-type APC.1 TASIN-1 is effective in vivo, inhibiting tumor growth of colorectal cancer (CRC) cells with truncated APC, but not wild-type CRC cells, in a mouse xenograft model.1 TASIN-1 decreases cholesterol biosynthesis in APC-truncated cells but not in wild-type APC cells.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhang, L., Theodoropoulos, P.C., Eskiocak, U., et al. Selective targeting of mutant adenomatous polyposis coli (APC) in colorectal cancer. Sci. Transl. Med. 8(361), 361ra140 (2016).