An HDAC1, HDAC2, and HDAC3 inhibitor
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CXD101

Item No. 21159

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(2-aminophenyl)-4-[1-[(1,3-dimethyl-1H-pyrazol-4-yl)methyl]-4-piperidinyl]-benzamide
CAS Number
934828-12-3
Synonyms
  • AZD 9468
  • HDAC-IN-4
  • Zabadinostat
Molecular Formula
C24H29N5O
Formula Weight
403.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlDMSO:PBS (pH 7.2)(1:5): 0.16 mg/mlEthanol: 1 mg/ml
λmax
232, 298 nm
SMILES
NC1=CC=CC=C1NC(C2=CC=C(C3CCN(CC4=CN(C)N=C4C)CC3)C=C2)=O
InChi Code
InChI=1S/C24H29N5O/c1-17-21(15-28(2)27-17)16-29-13-11-19(12-14-29)18-7-9-20(10-8-18)24(30)26-23-6-4-3-5-22(23)25/h3-10,15,19H,11-14,16,25H2,1-2H3,(H,26,30)
InChi Key
JHDZMASHNBKTPS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $72

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    1 mg

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    5 mg

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    10 mg

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    Cayman Chemical
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    Product Description

    CXD101 is a histone deacetylase 1 (HDAC1), HDAC2, and HDAC3 inhibitor (IC50s = 63, 570, and 550 nM, respectively).1 It increases acetylation of lysine 9 on histone H3 (H3K9Ac) in Colon-26 colon cancer cells when used at a concentration of 2.7 µM.2 CXD101 (50 mg/kg per day) decreases tumor volume, reduces tumor levels of macrophages, and increases tumor levels of Cd4+ and Cd8+ T cells without affecting body weight in a Colon-26 murine colon cancer model. It increases serum levels of IgG and IgM antibodies thirty days after administration in mice immunized with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Eyre, T.A., Collins, G.P., Gupta, A., et al. A phase 1 study to assess the safety, tolerability, and pharmacokinetics of CXD101 in patients with advanced cancer. Cancer 125(1), 99-108 (2019).

    2. Blaszczak, W., Liu, G., Zhu, H., et al. Immune modulation underpins the anti-cancer activity of HDAC inhibitors. Mol. Oncol. 15(12), 3280-3298 (2021).

    3. Liu, G., Barczak, W., Lee, L.N., et al. The HDAC inhibitor zabadinostat is a systemic regulator of adaptive immunity. Commun. Biol. 6(1), 102 (2023).