An inhibitor of NTPDase 1 and 3
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POM 1

Item No. 21160

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
tungstate (W12(OH)2O386-), hexasodium salt, monohydrate
CAS Number
314075-43-9
Synonyms
  • Sodium Metatungstate
  • Sodium Polyoxotungstate
Molecular Formula
H2O40W12 • H2O • 6Na
Formula Weight
3004.0
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 0.12 mg/mlDMSO: 0.16 mg/mlPBS (pH 7.2): 3 mg/ml
SMILES
O=[W+4]([O-2]1)([O-2][W+4]([OH-]2[W+4]34([O-2]5)([O-2]6)=O)([O-2]3)([O-2]7)([O-2]8)=O)([O-2][W+4]9%10([O-2][W+4]%11%12([O-2]%13)([O-2]%14)=O)([O-2][W+4]%15%16%14([O-2]%17)=O)=O)([O-2][W+4]8([O-2]%15[W+4]%18%176([O-2]%19)=O)([O-2]%18)([O-2]%16)=O)[OH-]9[W+4]1([O-2][W+4]([O-2]%11[W+4]%20%135%19=O)([O-2]%20)([O-2]%12)([O-2]%21)=O)([O-2][W+4]27%21([O-2]4)=O)([O-2]%10)=O.[Na+].O.[Na+].[Na+].[Na+].[Na+].[Na+]
InChi Code
InChI=1S/6Na.3H2O.38O.12W/h;;;;;;3*1H2;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;/q6*+1;;;;;;;;;;;;;;;;26*-2;12*+4/p-2
InChi Key
VBYQPULVKQWCQY-UHFFFAOYSA-L
Shipping & Storage Information
Storage
Room temperature
Shipping
Room temperature in continental US; may vary elsewhere
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    5 g

    $63

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    10 g

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    25 g

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    Product Description

    POM 1 is a polyoxometalate that inhibits ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) 1 and 3 with Ki values of 2.58 and 3.26 µM, respectively.1 It demonstrates 10-fold lower inhibitory activity for NTPDase 2 (Ki = 28.8 µM) and does not inhibit P2Y12 receptors (Ki > 10 µM).1 Inhibition of ecto-NTPDases that are capable of hydrolyzing nucleoside tri- and diphosphates (i.e., ATP, ADP, UTP, or UDP) can result in a potentiation of purinergic signaling due to an increase in the extracellular nucleotide concentrations. This subtype-selective NTPase inhibitor has been used to investigate the mechanisms of purinergic signaling.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Müller, C.E., Iqbal, J., Baqi, Y., et al. Polyoxometalates--a new class of potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors. Bioorg. Med. Chem. Lett. 16(23), 5943-5947 (2006).

    2. Pinheiro, A.R., Paramos-de-Carvalho, D., Certal, M., et al. Bradykinin-induced Ca2+ signaling in human subcutaneous fibroblasts involves ATP release via hemichannels leading to P2Y12 receptors activation. Cell Commun. Signal. 11, 70 (2013).