A fibrin monomer polymerization inhibitor
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H-Gly-Pro-Arg-Pro-OH (acetate)

Item No. 21163

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
glycyl-L-prolyl-L-arginyl-L-proline, monoacetate
CAS Number
157009-81-9
Synonyms
  • GPRP
Molecular Formula
C18H31N7O5 • C2H4O2
Formula Weight
485.5
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
λmax
208, 279 nm
SMILES
O=C(N1CCC[C@H]1C(O)=O)[C@H](CCCNC(N)=N)NC([C@@H]2CCCN2C(CN)=O)=O.OC(C)=O
InChi Code
InChI=1S/C18H31N7O5.C2H4O2/c19-10-14(26)24-8-2-5-12(24)15(27)23-11(4-1-7-22-18(20)21)16(28)25-9-3-6-13(25)17(29)30;1-2(3)4/h11-13H,1-10,19H2,(H,23,27)(H,29,30)(H4,20,21,22);1H3,(H,3,4)/t11-,12-,13-;/m0./s1
InChi Key
ZYTSTPIIKNCGRE-QKWXXBCPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $39

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    5 mg

    $77

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    10 mg

    $136

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    25 mg

    $241

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    Product Description

    H-Gly-Pro-Arg-Pro-OH (GPRP) is a peptide corresponding partly to the amino terminus of the Aα chain and Bβ chain of fibrin. It inhibits the spontaneous polymerization of fibrin monomers and also inhibits ADP-induced platelet aggregation (IC50 = 3 mM).1,2,3 GPRP binds to the fibrinogen D domain, inhibiting the ability of fibrinogen to bind to the platelet membrane glycoprotein GPIIb/IIIa.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Laudano, A.P., and Doolittle, R.F. Synthetic peptide derivatives that bind to fibrinogen and prevent the polymerization of fibrin monomers. Proc. Natl. Acad. Sci. USA 75(7), 3085-3089 (1978).

    2. Plow, E.F., and Marguerie, G. Inhibition of fibrinogen binding to human platelets by the tetrapeptide glycyl-L-prolyl-L-arginyl-L-proline. Proc. Natl. Acad. Sci. USA 79(12), 3711-3715 (1982).

    3. Adelman, B., Gennings, C., Stony, J., et al. Synergistic inhibition of platelet aggregation by fibrinogen-related peptides. Circ. Res. 67(4), 941-947 (1990).