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Clostebol

Item No. 21168

Restricted Product (Schedule III)
Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Synonyms
Synonyms
  • 4-chloro Testosterone
Technical Information
Formal Name
4-chloro-17β-hydroxy-androst-4-en-3-one
CAS Number
1093-58-9
Molecular Formula
C19H27ClO2
Formula Weight
322.9
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mLDMSO: 30 mg/mLDMSO:PBS (pH 7.2) (1:10): 0.09 mg/mLEthanol: 20 mg/mL
λmax
254 nm
SMILES
O[C@H]1CC[C@@]2([H])[C@]3([H])CCC4=C(Cl)C(CC[C@]4(C)[C@@]3([H])CC[C@@]21C)=O
InChi Code
InChI=1S/C19H27ClO2/c1-18-10-8-15(21)17(20)14(18)4-3-11-12-5-6-16(22)19(12,2)9-7-13(11)18/h11-13,16,22H,3-10H2,1-2H3/t11-,12-,13-,16-,18+,19-/m0/s1
InChi Key
KCZCIYZKSLLNNH-FBPKJDBXSA-N
Regulatory Information
DEA Schedule
III
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Clostebol (Item No. 21168) is an analytical reference standard that is categorized as an androgenic anabolic steroid. Clostebol is a chlorinated form of testosterone (Item Nos. 15645 | ISO60154) that has been used as an athletic performance enhancer and to fatten cattle.1,2,3 It is also detectible in urine. Formulations containing clostebol have been used to treat osteoporosis, anorexia, and certain types of liver disease.4,5,6 Clostebol is regulated as a Schedule III compound in the United States. This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lu, J., Fernández-Álvarez, M., Yang, S., et al. New clostebol metabolites in human urine by liquid chromatography time-of-flight tandem mass spectrometry and their application for doping control. J. Mass. Spectrom. 50(1), 191-197 (2015).

    2. Debruyckere, G., de Sagher, R., and Van Peteghem, C. Clostebol-positive urine after consumption of contaminated meat. Clin. Chem. 38(9), 1869-1873 (1992).

    3. Pereira, H.M., Marques, M.A., Talhas, I.B., et al. Incidental clostebol contamination in athletes after sexual intercourse. Clin. Chem. 50(2), 456-457 (2004).

    4. Schanzer, W., and Donike, M. Metabolism of anabolic steroids in man: Synthesis and use of reference substances for identification of anabolic steroid metabolites. Anal. Chim. Acta. 275(1-2), 23-48 (1993).

    5. Calderón-Garcidueñas, L., Wen-Wang, L., Zhang, Y.J., et al. 8-Hydroxy-2'-deoxyguanosine, a major mutagenic oxidative DNA lesion, and DNA strand breaks in nasal respiratory epithelium of children exposed to urban pollution. Environ. Health Perspect. 107(6), 469-474 (1999).

    6. Crabbe, P., Van Peteghem, C., Salden, M., et al. Influence of the hapten conjugation site on the characteristics of antibodies generated against metabolites of clostebol acetate. J. Agric. Food Chem. 48(8), 3633-3638 (2000).