A TLR2 and dectin-1 activator
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Zymosan A

Item No. 21175

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
CAS Number
58856-93-2
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: 100 µg/mlDMSO: 200 µg/mlEthanol: 100 µg/ml
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    250 mg

    $49

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    500 mg

    $93

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    1 g

    $132

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    Product Description

    Zymosan A is a glucan derived from the cell wall of S. cerevisiae that activates toll-like receptor 2 (TLR2) and a C-type lectin, dectin-1, on macrophages, monocytes, and dendritic cells to induce inflammatory signaling.1,2,3,4 It is commonly used to stimulate a sterile inflammatory response in mouse models of sepsis, shock, and peritonitis.5,6 In a mouse model of sepsis/shock, a lethal dose of zymosan A (500 mg/kg) in rats induced inflammation and shock leading to death.5 Zymosan A can also induce biosynthesis of eicosanoids.7

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Di Carlo, F.J., and Fiore, J.V. On the composition of zymosan. Science 127(3301), 756-757 (1958).

    2. Brown, G.D., and Gordon, S. Immune recognition: A new receptor for β-glucans. Nature 413(6851), 36-37 (2001).

    3. Pillemer, L., Blum, L., Lepow, I.H., et al. The properdin system and immunity. III. The zymosan assay of properdin. J. Exp. Med. 103(1), 1-13 (1956).

    4. Underhill, D.M., Ozinsky, A., Hajjar, A.M., et al. The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens. Nature 401(6755), 811-815 (1999).

    5. Reynolds, F.D., Dauchy, R., Blask, D.E., et al. The pineal gland hormone melatonin improves survival in a rat model of sepsis/shock induced by zymosan A. Surgery 134(3), 474-479 (2003).

    6. Rao, T.S., Currie, J.L., Shaffer, A.F., et al. In Vivo characterization of zymosan-induced mouse peritoneal inflammation. J. Pharmacol. Exp. Ther. 269(3), 917-925 (1994).

    7. Humes, J.L., Sadowski, S., Galavage, M., et al. Evidence for two sources of arachidonic acid for oxidative metabolism by mouse peritoneal macrophages. The Journal of Biological Chemisty 257(4), 1591-1594 (1982).