An inhibitor of polyQ aggregation
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C2-8

Item No. 21177

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(4-bromophenyl)-3-[[(4-bromophenyl)amino]sulfonyl]-benzamide
CAS Number
300670-16-0
Synonyms
  • Polyglutamine Aggregation Inhibitor III
Molecular Formula
C19H14Br2N2O3S
Formula Weight
510.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 33 mg/mlDMSO: 33 mg/mlDMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml
λmax
230, 274 nm
SMILES
BrC1=CC=C(NC(C2=CC=CC(S(NC3=CC=C(Br)C=C3)(=O)=O)=C2)=O)C=C1
InChi Code
InChI=1S/C19H14Br2N2O3S/c20-14-4-8-16(9-5-14)22-19(24)13-2-1-3-18(12-13)27(25,26)23-17-10-6-15(21)7-11-17/h1-12,23H,(H,22,24)
InChi Key
SJJKUNDBFWUAQB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $156

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    10 mg

    $268

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    25 mg

    $602

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    Product Description

    C2-8 is an inhibitor of polyglutamine (polyQ) aggregation (IC50s = 25 and 0.05 μM for recombinant HDQ51 and in PC12 cells, respectively).1 It also inhibits polyQ aggregation in organotypic hippocampal slice cultures isolated from R6/2 transgenic mice and reduces neurodegeneration in a dose-dependent manner in a Drosophila model of Huntington's disease. C2-8 (100 and 200 mg/kg) reduces huntingtin aggregate size, reduces neuronal atrophy, and improves motor performance in a rotarod test in the R6/2 transgenic mouse model of Huntington's disease.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhang, X., Smith, D.L., Meriin, A.B., et al. A potent small molecule inhibits polyglutamine aggregation in Huntington’s disease neurons and suppresses neurodegeneration in vivo. Proc. Natl. Acad. Sci. USA 102(3), 892-897 (2005).

    2. Chopra, V., Fox, J.H., Lieberman, G., et al. A small-molecule therapeutic lead for Huntington’s disease: Preclinical pharmacology and efficacy of C2-8 in the R6/2 transgenic mouse. Proc. Natl. Acad. Sci. USA 104(42), 16685-16689 (2007).