An inhibitor of microtubule assembly
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TN-16

Item No. 21222

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[1-(phenylamino)ethylidene]-5-(phenylmethyl)-2,4-pyrrolidinedione
CAS Number
33016-12-5
Synonyms
  • NSC 239274
Molecular Formula
C19H18N2O2
Formula Weight
306.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 12.5 mg/mLDMSO: 20 mg/mLDMSO:PBS(pH 7.2) (1:3): 0.25 mg/mLEthanol: 0.25 mg/mL
λmax
234, 319 nm
SMILES
O=C(/C1=C(C)\NC2=CC=CC=C2)NC(CC3=CC=CC=C3)C1=O
InChi Code
InChI=1S/C19H18N2O2/c1-13(20-15-10-6-3-7-11-15)17-18(22)16(21-19(17)23)12-14-8-4-2-5-9-14/h2-11,16,20H,12H2,1H3,(H,21,23)/b17-13-
InChi Key
KWSXUGYAGMSUTN-LGMDPLHJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $49

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    25 mg

    $107

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    50 mg

    $190

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    Product Description

    TN-16 is an inhibitor of microtubule polymerization (IC50 = 0.4-1.7 µM).1 It blocks taxol-induced assembly of tubulin (IC50 = 6 µM) and blocks colchicine (Item No. 9000760) binding to tubulin.1 Like colchicine, TN-16 inhibits alkylation of tubulin.2 TN-16 induces metaphase arrest in renal cell carcinoma cells.3 TN-16 can be used in combination with other inhibitors to enhance the efficiency of human artificial chromosome transfer to recipient cells.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Arai, T. Inhibition of microtubule assembly in vitro by TN-16, a synthetic antitumor drug. FEBS Lett. 155(2), 273-276 (1983).

    2. Roach, M.C., and Luduena, R.F. The effect of TN-16 on the alkylation of tubulin. Biochem. Biophys. Res. Commun. 129(1), 200-205 (1985).

    3. Nakamura, M., Kanda, S., Kawamura, M., et al. Effects of low concentration of vinblastine on the anchorage-independent growth and in vitro invasion of human renal carcinoma cell lines. Cancer Lett. 69(2), 85-91 (1993).

    4. Liskovykh, M., Lee, N.C.O., Larinov, V., et al. Moving toward a higher efficiency of microcell-mediated chromosome transfer. Mol. Ther. Methods Clin. Dev. 3, 16043 (2016).