A natural polyphenolic
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Digallic Acid

Item No. 21224

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,4-dihydroxy-5-[(3,4,5-trihydroxybenzoyl)oxy]-benzoic acid
CAS Number
536-08-3
Synonyms
  • m-Galloylgallic acid
  • NSC 59263
Molecular Formula
C14H10O9
Formula Weight
322.2
Purity
≥95% (mixture of para and meta isomers)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleMethanol: Soluble
SMILES
OC(C1=CC(OC(C2=CC(O)=C(O)C(O)=C2)=O)=C(O)C(O)=C1)=O
InChi Code
InChI=1S/C14H10O9/c15-7-2-6(3-8(16)11(7)18)14(22)23-10-4-5(13(20)21)1-9(17)12(10)19/h1-4,15-19H,(H,20,21)
InChi Key
COVFEVWNJUOYRL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
4°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $395

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    Product Description

    Digallic acid is a natural polyphenolic that can be produced by hydrolysis of gallotannins. Like other polyphenolic compounds, digallic acid has antioxidant activity that can be cytoprotective.1 Digallic acid inhibits reverse transcriptases from human immunodeficiency virus (Ki = 0.58 µM) and murine leukemia virus.2 It also inhibits calcium-activated chloride channels, blocking the initial agonist-stimulated chloride current.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bhouri, W., Derbel, S., Skandrani, I., et al. Study of genotoxic, antigenotoxic and antioxidant activities of the digallic acid isolated from Pistacia lentiscus fruits. Toxicol. In Vitro 24(2), 509-515 (2010).

    2. Nakane, H., Fukushima, M., and Ono, K. Differential inhibition of reverse transcriptase and various DNA polymerases by digallic acid and its derivatives. J. Nat. Prod. 53(5), 1234-1240 (1990).

    3. Namkung, W., Phuan, P.W., and Verkman, A.S. TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloride channel conductance in airway and intestinal epithelial cells. The Journal of Biological Chemisty 286(3), 2365-2374 (2011).