A DNA alkylating agent
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Lomustine

Item No. 21237

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(2-chloroethyl)-N'-cyclohexyl-N-nitroso-urea
CAS Number
13010-47-4
Synonyms
  • CCNU
  • NCI C04740
  • NSC 79037
Molecular Formula
C9H16CIN3O2
Formula Weight
233.7
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 100 mMEthanol: 100 mMWater: 25 mM
λmax
230 nm
SMILES
O=C(N(N=O)CCCl)NC1CCCCC1
InChi Code
InChI=1S/C9H16ClN3O2/c10-6-7-13(12-15)9(14)11-8-4-2-1-3-5-8/h8H,1-7H2,(H,11,14)
InChi Key
GQYIWUVLTXOXAJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

    $41

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    100 mg

    $75

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    250 mg

    $148

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    1 g

    $351

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    Cayman Chemical
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    Product Description

    Lomustine is a nitrosourea DNA alkylating agent that forms DNA interstrand crosslinks and strand breaks.1,2 It reduces tumor volume in a melanoma mouse xenograft model when administered at doses ranging from 4 to 16 mg/kg.3 Formulations containing lomustine have been used in the treatment of various cancers in human and veterinary medicine.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kohn, K.W. Interstrand cross-linking of DNA by 1,3-bis(2-chloroethyl)-1-nitrosourea and other 1-(2-haloethyl)-1-nitrosoureas. Cancer Res. 37(5), 1450-1454 (1977).

    2. Siddik, Z.H. Mechanisms of action of cancer chemotherapeutic agents: DNA-interactive alkylating agents and antitumour platinum-based drugs. The Cancer Handbook 1st Edition (2005).

    3. Osieka, R., Glatte, P., Pannenbäcker, R., et al. Therapeutic evaluation of five nitrosoureas in a human melanoma xenograft system. Cancer Chemother. Pharmacol. 11(3), 147-152 (1983).