A chemotherapy adjuvant with antioxidant properties
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Mesna

Item No. 21238

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-mercapto-ethanesulfonic acid, monosodium salt
CAS Number
19767-45-4
Synonyms
  • Coenzyme M
  • HS-CoM
  • 2-Mercaptoethanesulfonate
  • UCB 3983
Molecular Formula
C2H5O3S2 • Na
Formula Weight
164.2
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 20 mg/mlPBS (pH 7.2): 5 mg/ml
SMILES
[O-]S(CCS)(=O)=O.[Na+]
InChi Code
InChI=1S/C2H6O3S2.Na/c3-7(4,5)2-1-6;/h6H,1-2H2,(H,3,4,5);/q;+1/p-1
InChi Key
XOGTZOOQQBDUSI-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 g

    $63

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    10 g

    $118

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    Product Description

    Mesna is a cofactor found in methanogenic archaea that is essential for the final step of methanogenesis and is also important for alkene metabolism.1 It functions as an antioxidant and cytoprotective agent and is widely used for protection from toxicity of chemotherapeutic agents.2 In the bladder, mesna conjugates to urotoxic metabolites such as acrolein through a Michael addition, converting the toxic compound into inactive metabolites that can be excreted in the urine.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Krishnakumar, A.M., Sliwa, D., Endrizzi, J.A., et al. Getting a handle on the role of coenzyme M in alkene metabolism. Microbiol. Mol. Biol. Rev. 72(3), 445-456 (2008).

    2. Monach, P.A., Arnold, L.M., and Merkel, P.A. Incidence and prevention of bladder toxicity from cyclophosphamide in the treatment of rheumatic diseases: A data-driven review. Arthritis Rheum. 62(1), 9-21 (2010).