A calcium channel blocker
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Azelnidipine

Item No. 21249

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid, 3-[1-(diphenylmethyl)-3-azetidinyl] 5-(1-methylethyl) ester
CAS Number
123524-52-7
Synonyms
  • CS 905
  • RS 9054
Molecular Formula
C33H34N4O6
Formula Weight
582.7
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS(pH 7.2) (1:3): 0.25 mg/mlEthanol: 15 mg/ml
λmax
255, 343 nm
SMILES
CC1=C(C(OC(C)C)=O)C(C2=CC([N+]([O-])=O)=CC=C2)C(C(OC3CN(C(C4=CC=CC=C4)C5=CC=CC=C5)C3)=O)=C(N)N1
InChi Code
InChI=1S/C33H34N4O6/c1-20(2)42-32(38)27-21(3)35-31(34)29(28(27)24-15-10-16-25(17-24)37(40)41)33(39)43-26-18-36(19-26)30(22-11-6-4-7-12-22)23-13-8-5-9-14-23/h4-17,20,26,28,30,35H,18-19,34H2,1-3H3
InChi Key
ZKFQEACEUNWPMT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 mg

    $63

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    1 g

    $94

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    5 g

    $321

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    Product Description

    Azelnidipine is a third generation, dihydropyridine L-type calcium channel blocker with a slow onset profile that displays long-lasting antihypertensive activity in hypertensive rat models compared to other L-type calcium channel blockers.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Oizumi, K., Nishino, H., Koike, H., et al. Antihypertensive effects of CS-905, a novel dihydropyridine Ca++ channel blocker. Jpn. J. Pharmacol. 51(1), 57-64 (1989).

    2. Chen, B.-L., Zhang, Y.-Z., Luo, J.-Q., et al. Clinical use of azelnidipine in the treatment of hypertension in Chinese patients. Ther. Clin. Risk Manag. 11, 309-318 (2015).