An inhibitor of microtubule polymerization
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Vinorelbine (tartrate)

Item No. 21262

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2β,3β,4β,5α,12R,19α)-4-(acetyloxy)-6,7-didehydro-15-[(2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-aspidospermidine-3-carboxylic acid, methyl ester, 2R,3R-dihydroxybutanedioate (1:2)
CAS Number
125317-39-7
Synonyms
  • KW 2307
Molecular Formula
C45H54N4O8 • 2C4H6O6
Formula Weight
1079.1
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 46 mg/mlWater: 10 mg/ml
λmax
214, 269, 313 nm
SMILES
[H][C@@]1([C@](C(OC)=O)(O)[C@H](OC(C)=O)[C@@]2(C=CCN3CC[C@]41[C@@]32[H])CC)N(C)C5=C4C=C([C@@]6(C(OC)=O)C[C@]7([H])C=C(CC)C[N@@](C7)CC8=C6NC9=C8C=CC=C9)C(OC)=C5.O[C@H]([C@H](C(O)=O)O)C(O)=O.O[C@H]([C@H](C(O)=O)O)C(O)=O
InChi Code
InChI=1S/C45H54N4O8.2C4H6O6/c1-8-27-19-28-22-44(40(51)55-6,36-30(25-48(23-27)24-28)29-13-10-11-14-33(29)46-36)32-20-31-34(21-35(32)54-5)47(4)38-43(31)16-18-49-17-12-15-42(9-2,37(43)49)39(57-26(3)50)45(38,53)41(52)56-7;2*5-1(3(7)8)2(6)4(9)10/h10-15,19
InChi Key
CILBMBUYJCWATM-PYGJLNRPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

    $69

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    10 mg

    $120

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    25 mg

    $233

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    50 mg

    $329

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    Cayman Chemical
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    Product Description

    Vinorelbine is a semisynthetic vinca alkaloid with microtubule destabilizing activity.1,2 It inhibits microtubule polymerization and blocks mitosis at the metaphase/anaphase transition, preventing HeLa cell proliferation with an IC50 value of 1.25 nM.3 In in vitro and in vivo models, vinorelbine has demonstrated additive effects when combined with other antimitotic agents to reduce the proliferation of various solid tumor, lymphoma, or lung cancer cell lines.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jordan, M.A., and Wilson, L. Microtubules as a target for anticancer drugs. Nat. Rev. Cancer 4(4), 253-265 (2004).

    2. Kingston, D.G.I. Tubulin-interactive natural products as anticancer agents. J. Nat. Prod. 72(3), 507-515 (2009).

    3. Ngan, V.K., Bellman, K., Hill, B.T., et al. Mechanism of mitotic block and inhibition of cell proliferation by the semisynthetic Vinca alkaloids vinorelbine and its newer derivative vinflunine. Mol. Pharmacol. 60(1), 225-232 (2001).