MMP-9/MMP-13 Inhibitor I

MMP-9/MMP-13 inhibitor I is a cell-permeable inhibitor of matrix metalloproteinases (MMPs) that most potently inhibits MMP-9 and MMP-13 (IC₅₀s = 0.9 nM for both).¹ It less effectively inhibits MMP-1, MMP-3, and MMP-7 (IC₅₀s = 43, 23, and 920 nM, respectively).¹ MMP-9/MMP-13 inhibitor I has been used to elucidate the roles of MMPs in biological systems, including tumor cell invasion and pathogenesis of P. falciparum.^2,3,4

WARNING This product is not for human or veterinary use.

1. Cheng, M., De, B., Pikul, S., et al. Design and synthesis of piperazine-based matrix metalloproteinase inhibitors. J. Med. Chem. 43(3), 369-380 (2000).

2. Prato, M., Giribaldi, G., Polimeni, M., et al. Phagocytosis of hemozoin enhances matrix metalloproteinase-9 activity and TNF-α production in human monocytes: Role of matrix metalloproteinases in the pathogenesis of falciparum malaria. J. Immunol. 175(10), 6436-6442 (2005).

3. Storz, P., Döppler, H., Copland, J.A., et al. FOXO3a promotes tumor cell invasion through the induction of matrix metalloproteinases. Mol. Cell. Biol. 29(18), 4906-4917 (2009).

4. Swamydas, M., Ricci, K., Rego, S.L., et al. Mesenchymal stem cell-derived CCL-9 and CCL-5 promote mammary tumor cell invasion and the activation of matrix metalloproteinases. Cell Adh. Migr. 7(3), (2013).