An inhibitor of GSNOR
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N6022

Item No. 21269

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[4-(aminocarbonyl)-2-methylphenyl]-5-[4-(1H-imidazol-1-yl)phenyl]-1H-pyrrole-2-propanoic acid
CAS Number
1208315-24-5
Molecular Formula
C24H22N4O3
Formula Weight
414.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mLDMSO: 30 mg/mLEthanol: 1 mg/mLPBS (pH 7.2): 0.1 mg/mL
λmax
304 nm
SMILES
NC(C(C=C1)=CC(C)=C1N2C(CCC(O)=O)=CC=C2C3=CC=C(N4C=NC=C4)C=C3)=O
InChi Code
InChI=1S/C24H22N4O3/c1-16-14-18(24(25)31)4-9-21(16)28-20(8-11-23(29)30)7-10-22(28)17-2-5-19(6-3-17)27-13-12-26-15-27/h2-7,9-10,12-15H,8,11H2,1H3,(H2,25,31)(H,29,30)
InChi Key
YVPGZQLRPAGKLA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $33

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    5 mg

    $74

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    10 mg

    $130

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    25 mg

    $242

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    Product Description

    N6022 is a tight-binding, specific, and fully reversible inhibitor of S-nitrosoglutathione reductase (GSNOR; IC50 = 8 nM; Ki = 2.5 nM).1 It is reported to bind in the GSNO substrate binding pocket like a competitive inhibitor, although in kinetic assays it behaves with a mixed uncompetitive mode of inhibition toward the GSNO substrate and a mixed competitive mode of inhibition toward the formaldehyde adduct, S-hydroxymethylglutathione.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Green, L.S., Chun, L.E., Patton, A.K., et al. Mechanism of inhibition for N6022, a first-in-class drug targeting S-nitrosoglutathione reductase. Biochemistry 51(10), 2157-2168 (2012).