A Notch inhibitor
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FLI-06

Item No. 21272

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylic acid, cyclohexyl ester
CAS Number
313967-18-9
Molecular Formula
C25H30N2O5
Formula Weight
438.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMF:PBS (pH 7.2) (1:4): 0.2 mg/mlDMSO: 10 mg/mlEthanol: 1 mg/ml
λmax
242, 282, 374 nm
SMILES
CC1(C)CC(C(C(C2=CC=C([N+]([O-])=O)C=C2)C(C(OC3CCCCC3)=O)=C(C)N4)=C4C1)=O
InChi Code
InChI=1S/C25H30N2O5/c1-15-21(24(29)32-18-7-5-4-6-8-18)22(16-9-11-17(12-10-16)27(30)31)23-19(26-15)13-25(2,3)14-20(23)28/h9-12,18,22,26H,4-8,13-14H2,1-3H3
InChi Key
SWWVFYHSSOWZMF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $90

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    10 mg

    $161

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    25 mg

    $349

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    50 mg

    $653

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    Product Description

    FLI-06 is a first-of-its-kind inhibitor of Notch signaling (EC50 = 2.3 µM) that acts upstream of α-secretase and β-secretase cleavage.1 It disrupts the intracellular trafficking and processing of the Notch signaling pathway, inhibiting general secretion at a stage before exit from the endoplasmic reticulum (ER) and converting ER morphology from tubule to sheet.1 FLI-06 is reported to alter the maturation pattern of amyloid precursor protein (APP) and prevent the shedding of APPs in HEK293 cells stably expressing a mutated APP that yields robust amounts of amyloid β.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Krämer, A., Mentrup, T., Kleizen, B., et al. Small molecules intercept Notch signaling and the early secretory pathway. Nat. Chem. Biol. 9(11), 731-738 (2013).