An NS5A inhibitor
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Velpatasvir

Item No. 21280

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(1R)-2-[(2S,4S)-2-[5-[1,11-dihydro-2-[(2S,5S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methyl-1-oxobutyl]-5-methyl-2-pyrrolidinyl][2]benzopyrano[4',3':6,7]naphth[1,2-d]imidazol-9-yl]-1H-imidazol-2-yl]-4-(methoxymethyl)-1-pyrrolidinyl]-2-oxo-1-phenylethyl]-carbamic acid, methyl ester
CAS Number
1377049-84-7
Synonyms
  • GS-5816
Molecular Formula
C49H54N8O8
Formula Weight
883.0
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 20 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2) (1:2): 0.33 mg/ml
λmax
269, 303, 339 nm
SMILES
O=C([C@H](C(C)C)NC(OC)=O)N([C@@H](C)CC1)[C@@H]1C(N2)=NC3=C2C4=CC(OC5)=C(C=C4C=C3)C6=C5C=C(C7=CN=C([C@@H]8C[C@H](COC)CN8C([C@H](NC(OC)=O)C9=CC=CC=C9)=O)N7)C=C6
InChi Code
InChI=1S/C49H54N8O8/c1-26(2)41(54-48(60)63-5)47(59)57-27(3)12-17-38(57)45-51-36-16-14-30-20-35-33-15-13-31(19-32(33)25-65-40(35)21-34(30)43(36)53-45)37-22-50-44(52-37)39-18-28(24-62-4)23-56(39)46(58)42(55-49(61)64-6)29-10-8-7-9-11-29/h7-11,13-16,19-2
InChi Key
FHCUMDQMBHQXKK-CDIODLITSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    10 mg

    $36

    Add

    50 mg

    $95

    Add

    100 mg

    $153

    Add

    250 mg

    $328

    Add
    Cayman Chemical
    Neutrophil Biology Wall Poster

    Explore how neutrophils shape the immune response in health and disease. This poster highlights neutrophil pathogen defense mechanisms, including phagocytosis, degranulation, and NETosis, as well as neutrophil roles in inflammation and NET-associated pathologies.

    DOWNLOAD NOW
    Product Description

    Velpatasvir is a pan-genotypic hepatitis C virus (HCV) non-structural protein 5A (NS5A) inhibitor.1 It inhibits replication of HCV genotypes 1-6 (EC50s = 6-130 pM in replicon assays). Velpatasvir (100 µM) also inhibits severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exonuclease activity and enhances remdesivir-induced inhibition of SARS-CoV-2 replication in infected Calu-3 human lung epithelial cells when used at a concentration of 10 µM.2 Formulations containing velpatasvir have been used in combination with sofosbuvir in the treatment of HCV infection.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lawitz, E., Freilich, B., Link, B., et al. A phase 1, randomized, dose-ranging study of GS-5816, a once-daily NS5A inhibitor, in patients with genotype 1-4 hepatitis C virus. J. Viral. Hepat. 22(12), 1011-1019 (2015).

    2. Nguyenla, X., Wehri, E., Van Dis, E., et al. Discovery of SARS-CoV-2 antiviral synergy between remdesivir and approved drugs in human lung cells. Sci. Rep. 12(1), 18506 (2022).