A Ral inhibitor
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RBC8

Item No. 21281

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-amino-4-(2,5-dimethoxyphenyl)-1,4-dihydro-3-(2-naphthalenyl)-pyrano[2,3-c]pyrazole-5-carbonitrile
CAS Number
361185-42-4
Molecular Formula
C25H20N4O3
Formula Weight
424.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mLDMSO: 30 mg/mLDMSO:PBS(pH 7.2) (1:2): 0.33 mg/mLEthanol: 0.25 mg/mL
λmax
252 nm
SMILES
NC1=C(C#N)C(C2=CC(OC)=CC=C2OC)C3=C(NN=C3C4=CC(C=CC=C5)=C5C=C4)O1
InChi Code
InChI=1S/C25H20N4O3/c1-30-17-9-10-20(31-2)18(12-17)21-19(13-26)24(27)32-25-22(21)23(28-29-25)16-8-7-14-5-3-4-6-15(14)11-16/h3-12,21H,27H2,1-2H3,(H,28,29)
InChi Key
CLMQBVUFKIKYLU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    25 mg

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    Cayman Chemical
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    Product Description

    RBC8 is a small molecule inhibitor of the Ras-like GTPases RalA and RalB that prevents binding of the GTPase to the Ral-binding protein.1 RBC8 has been shown to prevent Ral-mediated spreading of murine embryonic fibroblasts, block anchorage-independent growth of H2122 and H358 lung cancer cell lines (IC50s = 3.5 and 3.4 µM, respectively), and inhibit the growth of H2122 lung cancer xenografts in mice (50 mg/kg i.p.).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yan, C., Liu, D., Li, L., et al. Discovery and characterization of small molecules that target the GTPase Ral. Nature 515(7527), 443-447 (2014).