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Indapamide

Item No. 21308

Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Synonyms
Synonyms
  • (±)-Indapamide
Technical Information
Formal Name
3-(aminosulfonyl)-4-chloro-N-(2,3-dihydro-2-methyl-1H-indol-1-yl)-benzamide
CAS Number
26807-65-8
Molecular Formula
C16H16ClN3O3S
Formula Weight
365.8
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
Chloroform: SlightlyDMSO: 70 mg/mlEthanol: 70 mg/mlWater: <1 mgml
λmax
242, 286 nm
SMILES
ClC1=C(S(N)(=O)=O)C=C(C(NN2C(C)CC3=C2C=CC=C3)=O)C=C1
InChi Code
InChI=1S/C16H16ClN3O3S/c1-10-8-11-4-2-3-5-14(11)20(10)19-16(21)12-6-7-13(17)15(9-12)24(18,22)23/h2-7,9-10H,8H2,1H3,(H,19,21)(H2,18,22,23)
InChi Key
NDDAHWYSQHTHNT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Indapamide (Item No. 21308) is an analytical reference standard that is categorized as a sulfonamide diuretic that blocks delayed-rectifier potassium currents.1 Formulations containing indapamide are used to treat hypertension, but it is abused by athletes to reduce body weight rapidly or mask the presence of other athletic-enhancing substances.2,3 Indapamide can be detected in urine.4 This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Turgeon, J., Daleau, P., Bennett, P.B., et al. Block of IKS, the slow component of the delayed rectifier K+ current, by the diuretic agent indapamide in guinea pig myocytes. Circ. Res. 75(5), 879-886 (2017).

    2. Robinson, D.M., and Wellington, K. Indapamide sustained release: A review of its use in the treatment of hypertension. Drugs 66(2), 257-271 (2006).

    3. Cadwallader, A.B., de la Torre, X., Tieri, A., et al. The abuse of diuretics as performance-enhancing drugs and masking agents in sport doping: Pharmacology, toxicology and analysis. Br. J. Pharmacol. 161(1), 1-16 (2010).

    4. Ramkumar, A., Ponnusamya, V.K., and Jen, J.-F. Rapid determination of indapamide in human urine using novel low-density solvent based ultrasound assisted emulsification microextraction coupled with high performance liquid chromatography-variable wavelength detection. Anal. Methods 5, 2572-2577 (2013).