An inhibitor of activated coagulation factor VIIA
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

PCI 27483

Item No. 21334

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-[5-[6-(aminoiminomethyl)-1H-benzimidazol-2-yl]-5'-(aminosulfonyl)-2',6-dihydroxy[1,1'-biphenyl]-3-yl]acetyl]-L-aspartic acid
CAS Number
871266-63-6
Molecular Formula
C26H24N6O9S
Formula Weight
596.6
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 10 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
λmax
230, 307, 340 nm
SMILES
NS(C1=CC(C2=CC(CC(N[C@H](C(O)=O)CC(O)=O)=O)=CC(C3=NC(C=CC(C(N)=N)=C4)=C4N3)=C2O)=C(O)C=C1)(=O)=O
InChi Code
InChI=1S/C26H24N6O9S/c27-24(28)12-1-3-17-18(8-12)32-25(31-17)16-6-11(7-21(34)30-19(26(38)39)10-22(35)36)5-15(23(16)37)14-9-13(42(29,40)41)2-4-20(14)33/h1-6,8-9,19,33,37H,7,10H2,(H3,27,28)(H,30,34)(H,31,32)(H,35,36)(H,38,39)(H2,29,40,41)/t19-/m0/s1
InChi Key
WDJHHCAKBRKCLW-IBGZPJMESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $53

    Add

    5 mg

    $231

    Add

    10 mg

    $332

    Add

    25 mg

    $700

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    PCI 27483 is a small molecule inhibitor of activated coagulation factor VIIa with antithrombotic effects in a baboon model of arterial thrombosis.1 It also inhibits the growth of BxPC3 xenografts by 42 and 85% at doses of 60 and 90 mg/kg, respectively.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gómez-Outes, A., Suárez-Gea, L., Lecumberri, R., et al. New parenteral anticoagulants in development. Ther. Adv. Cardiovasc. Disc. 5(1), 33-59 (2011).

    2. Prescott, J., Thiemann, P., and Loury, D. PCI-27483, a small molecule inhibitor of Factor VIIa, inhibits growth of BxPC3 pancreatic adenocarcinoma xenograft tumors. AACR Annual Meeting (2008).