A nucleoside analog
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Sangivamycin (hydrate)

Item No. 21343

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-amino-7-β-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidine-5-carboxamide, hydrate
Synonyms
  • NSC 65346
Molecular Formula
C12H15N5O5 • XH2O
Formula Weight
309.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly Soluble: 0.1-1 mg/mlDMSO: Slightly Soluble: 0.1-1 mg/mlH2O: Slightly Soluble: 0.1-1 mg/ml
SMILES
OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C=C(C(N)=O)C3=C2N=CN=C3N)O1.O
InChi Code
InChI=1S/C12H15N5O5.H2O/c13-9-6-4(10(14)21)1-17(11(6)16-3-15-9)12-8(20)7(19)5(2-18)22-12;/h1,3,5,7-8,12,18-20H,2H2,(H2,14,21)(H2,13,15,16);1H2/t5-,7-,8-,12-;/m1./s1
InChi Key
QTYUIEDCERYPNJ-CCUUNMJDSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $87

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    5 mg

    $392

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    10 mg

    $566

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    25 mg

    $978

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    Cayman Chemical
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    Product Description

    Sangivamycin is a nucleoside analog.1 It incorporates into severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA and reduces the number of plaque-forming units (PFUs) in SARS-CoV-2-infected Vero E6 cells when used at a concentration of 72 nM. Sangivamycin (0.3 µM) induces cell cycle arrest at the G2/M phase and apoptosis in MCF-7/adr cells, effects that can be prevented by the JNK inhibitor SP600125 (Item No. 10010466) or protein kinase Cδ (PKCδ) inhibitor rottlerin (Item No. 12006).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bennett, R.P., Yoluç, Y., Salter, J.D., et al. Sangivamycin is preferentially incorporated into viral RNA by the SARS-CoV-2 polymerase. Antiviral Res. 218, 105716 (2023).

    2. Lee, S.A., and Jung, M. The nucleoside analog sangivamycin induces apoptotic cell death in breast carcinoma MCF7/adriamycin-resistant cells via protein kinase Cdelta and JNK activation. The Journal of Biological Chemisty 282(20), 15271-15283 (2007).