A macrolide antibiotic
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Davercin

Item No. 21348

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
cyclic 11,12-carbonate erythromycin
CAS Number
55224-05-0
Synonyms
  • Erythromycin cyclocarbonate
Molecular Formula
C38H65NO14
Formula Weight
759.9
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMSO: 15 mg/mlEthanol: 30 mg/mlEthanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
λmax
205 nm
SMILES
C[C@H]1[C@H](O)[C@@](OC)(C)C[C@@](O[C@H]([C@@H](C)C(O[C@H](CC)[C@]2(C)[C@@](OC(O2)=O)([H])[C@H]3C)=O)[C@H](C)[C@@H](O[C@@]4([H])[C@H](O)[C@@H](N(C)C)C[C@@H](C)O4)[C@](C)(O)C[C@@H](C)C3=O)([H])O1
InChi Code
InChI=1S/C38H65NO14/c1-14-25-38(10)32(52-35(44)53-38)20(4)27(40)18(2)16-36(8,45)31(51-34-28(41)24(39(11)12)15-19(3)47-34)21(5)29(22(6)33(43)49-25)50-26-17-37(9,46-13)30(42)23(7)48-26/h18-26,28-32,34,41-42,45H,14-17H2,1-13H3/t18-,19-,20+,21+,22-,23+,2
InChi Key
NKLGIWNNVDPGCA-ZDYKNUMJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Cayman Chemical
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    Product Description

    Davercin is a macrolide antibiotic that inhibits bacterial protein synthesis by targeting the 50S ribosomal subunit, blocking the progression of nascent polypeptide chains.1 It has broad-spectrum activity against various Gram-positive and Gram-negative bacteria (MICs = 0.02-50 μg/ml). Davercin is non-toxic to mice and rats (LD50s = 4.05 and 5.9 g/kg, respectively). Formulations containing davercin have been used to treat a variety of urogenital bacterial infections.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bojarska-Dahlig, H., Slawinski, W., Roślik-Kamińska, D., et al. L-aspartate of erythromycin A cyclic 11,12-carbonate, a new semisynthetic erythromycin derivative. J. Antibiot. (Tokyo) 29(9), 907-914 (1976).