A non-selective NSAID
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Suprofen

Item No. 21350

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
α-methyl-4-(2-thienylcarbonyl)-benzeneacetic acid
CAS Number
40828-46-4
Synonyms
  • NSC 303611
  • R 25061
  • (±)-Suprofen
  • TN 762
Molecular Formula
C14H12O3S
Formula Weight
260.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 20 mg/mlPBS (pH 7.2): 0.5 mg/ml
λmax
266, 290 nm
SMILES
CC(C(O)=O)C1=CC=C(C(C2=CC=CS2)=O)C=C1
InChi Code
InChI=1S/C14H12O3S/c1-9(14(16)17)10-4-6-11(7-5-10)13(15)12-3-2-8-18-12/h2-9H,1H3,(H,16,17)
InChi Key
MDKGKXOCJGEUJW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $28

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    10 mg

    $53

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    25 mg

    $125

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    50 mg

    $220

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    Product Description

    Suprofen is a non-steroidal anti-inflammatory drug (NSAID) that non-selectively inhibits both isoforms of cyclooxygenase (COX; IC50s = 1.1 and 8.7 µM for COX-1 and COX-2, respectively).1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Warner, T.D., Giuliano, F., Vojnovic, I., et al. Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: A full in vitro analysis. Proc. Natl. Acad. Sci. USA 96(13), 7563-7568 (1999).

    2. Barnett, J., Chow, J., Ives, D., et al. Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system. Biochim. Biophys. Acta 1209(1), 130-139 (1994).