A sodium channel opener
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(±)-SDZ-201 106

Item No. 21356

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[3-[4-(diphenylmethyl)-1-piperazinyl]-2-hydroxypropoxy]-1H-indole-2-carbonitrile
CAS Number
97730-95-5
Synonyms
  • DPI 201-106
Molecular Formula
C29H30N4O2
Formula Weight
466.6
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 1.6 mg/ml
λmax
229, 283 nm
SMILES
OC(COC1=CC=CC2=C1C=C(C#N)N2)CN(CC3)CCN3C(C4=CC=CC=C4)C5=CC=CC=C5
InChi Code
InChI=1S/C29H30N4O2/c30-19-24-18-26-27(31-24)12-7-13-28(26)35-21-25(34)20-32-14-16-33(17-15-32)29(22-8-3-1-4-9-22)23-10-5-2-6-11-23/h1-13,18,25,29,31,34H,14-17,20-21H2
InChi Key
BYBYHCOEAFHGJL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $36

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    25 mg

    $62

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    Product Description

    (±)-SDZ-201 106 is a diphenylpiperazinylindole derivative that prolongs the open state of cardiac voltage-gated Na+ channels. It has been shown to increase net Na+ influx and the activity of reverse mode Na+/Ca2+ exchange, which leads to an increase in intracellular Ca2+, as well as to partially inhibit the Na+ pump in cardiac myocytes.1 (±)-SDZ-201 106 is also reported to act as an open-channel blocker of delayed-rectifier K+ channels in NG108-15 neuronal cells.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kaumann, A.H., Richards, D.E., and Russell, D.A. Inhibition of the sodium pump by cardioactive DPI 201-106. Br. J. Pharmacol. 91(1), 3-5 (1987).

    2. Wang, Y.-J., Lin, M.-W., Lin, A.-A., et al. Evidence for state-dependent block of DPI 201-106, a synthetic inhibitor of Na+ channel inactivation, on delayed-rectifier K+ current in pituitary tumor (GH3) cells. J. Physiol. Pharmacol. 59(3), 409-423 (2008).