A thymidine analog that inhibits DNA synthesis
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Trifluorothymidine

Item No. 21366

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
α,α,α-trifluoro-thymidine
CAS Number
70-00-8
Synonyms
  • NSC 75520
  • NSC 529182
  • TFT
  • Trifluridine
Molecular Formula
C10H11F3N2O5
Formula Weight
296.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 16 mg/mlDMSO: 10 mg/mlPBS (pH 7.2): 5 mg/ml
λmax
262 nm
SMILES
O=C(C(C(F)(F)F)=CN1[C@@H]2O[C@H](CO)[C@@H](O)C2)NC1=O
InChi Code
InChI=1S/C10H11F3N2O5/c11-10(12,13)4-2-15(9(19)14-8(4)18)7-1-5(17)6(3-16)20-7/h2,5-7,16-17H,1,3H2,(H,14,18,19)/t5-,6+,7+/m0/s1
InChi Key
VSQQQLOSPVPRAZ-RRKCRQDMSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 mg

    $117

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    250 mg

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    500 mg

    $427

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    1 g

    $740

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    Cayman Chemical
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    Product Description

    Trifluorothymidine is a derivative of thymidine that exhibits antiviral and anticancer activity by inhibiting thymidylate synthase, thereby blocking nucleic acid synthesis, and by incorporating into DNA, which leads to DNA damage and apoptosis.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Suzuki, N., Emura, T., and Fukushima, M. Mode of action of trifluorothymidine (TFT) against DNA replication and repair enzymes. Int. J. Oncol. 39(1), 263-270 (2011).