An antipsychotic
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Nemonapride

Item No. 21376

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
rel-5-chloro-2-methoxy-4-(methylamino)-N-[(2R,3R)-2-methyl-1-(phenylmethyl)-3-pyrrolidinyl]-benzamide
CAS Number
75272-39-8
Synonyms
  • YM-09151-2
Molecular Formula
C21H26ClN3O2
Formula Weight
387.9
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMF:PBS (pH 7.2) (1:9): 0.1 mg/mlDMSO: 10 mg/mlEthanol: 10 mg/ml
λmax
212, 282, 308 nm
SMILES
CNC1=C(Cl)C=C(C(N[C@H]2[C@@H](C)N(CC3=CC=CC=C3)CC2)=O)C(OC)=C1
InChi Code
InChI=1S/C21H26ClN3O2/c1-14-18(9-10-25(14)13-15-7-5-4-6-8-15)24-21(26)16-11-17(22)19(23-2)12-20(16)27-3/h4-8,11-12,14,18,23H,9-10,13H2,1-3H3,(H,24,26)/t14-,18-/m1/s1
InChi Key
KRVOJOCLBAAKSJ-RDTXWAMCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $44

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    5 mg

    $154

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    10 mg

    $242

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    25 mg

    $550

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    Product Description

    Nemonapride is an antipsychotic that readily passes through the blood brain barrier and exhibits potent neuroleptic effects in animals.1 It binds dopamine 2 (D2)-like receptors preferentially over D1-like receptors (Kis = 0.06, 0.3, and 0.15 nM for D2, D3, and D4, respectively).1,2 Nemonapride also binds sigma 1 (σ1) and σ2 receptors (Kis = 8.4 and 9.6 nM, respectively) and activates the serotonin 1A receptor (5-HT1A; IC50 = 34 nM).3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Terai, M., Usuda, S., Kuroiwa, I., et al. Selective binding of YM-09151-2, a new potent neuroleptic, to D2-dopaminergic receptors. Jpn. J. Pharmacol. 33(4), 749-755 (1983).

    2. Seeman, P., and Van Tol, H.H.M. Dopamine receptor pharmacology. Trends Pharmacol. Sci. 15(7), 264-270 (1994).

    3. Ujike, H., Akiyama, K., and Kuroda, S. [3H]YM-09151-2 (nemonapride), a potent radioligand for both sigma 1 and sigma 2 receptor subtypes. Neuroreport 7(5), 1057-1061 (1996).

    4. Assié, M.-B., Cosi, C., and Koek, W. 5-HT1A receptor agonist properties of the antipsychotic, nemonapride: comparison with bromerguride and clozapine. Eur. J. Pharmacol. 334(2-3), 141-147 (1997).