A mast cell stabilizer
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Product Categories

Product Type

Biochemicals

Research Area

Immunology & Inflammation
Allergy
Innate Immunity

Cromolyn (sodium salt hydrate)

Item No. 21379

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5,5'-((2-hydroxypropane-1,3-diyl)bis(oxy))bis(4-oxo-4H-chromene-2-carboxylate) sodium hydrate
Molecular Formula
C23H14O11 • 2Na [XH2O]
Formula Weight
512.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 1 mg/mlPBS (pH 7.2): 5 mg/ml
λmax
222, 239, 326 nm
SMILES
OC(COC1=C(C(OC(C([O-])=O)=C2)=CC=C1)C2=O)COC3=C(C(OC(C([O-])=O)=C4)=CC=C3)C4=O.[Na+].[Na+].O
InChi Code
InChI=1S/C23H16O11.2Na.H2O/c24-11(9-31-14-3-1-5-16-20(14)12(25)7-18(33-16)22(27)28)10-32-15-4-2-6-17-21(15)13(26)8-19(34-17)23(29)30;;;/h1-8,11,24H,9-10H2,(H,27,28)(H,29,30);;;1H2/q;2*+1;/p-2
InChi Key
LIZBBKUQXFWZCB-UHFFFAOYSA-L
Shipping & Storage Information
Storage
Room temperature
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

    $49

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    5 g

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    10 g

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    25 g

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    Cayman Chemical
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    Product Description

    Cromolyn is a chromone complex that acts as a mast cell stabilizer, preventing the release of histamine. Its mechanism of action is thought to involve an interference with the antigen-stimulated calcium transport across the mast cell membrane, thereby inhibiting mast cell release of histamine, leukotrienes, and other substances that cause hypersensitivity reactions.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shishibori, T., Oyama, Y., Matsushita, O., et al. Three distinct anti-allergic drugs, amlexanox, cromolyn and tranilast, bind to S100A12 and S100A13 of the S100 protein family. Biochem. J. 338, 583-589 (1999).

    2. Amin, K. The role of mast cells in allergic inflammation. Respir. Med. 106, 9-14 (2012).