An α1-adrenergic receptor antagonist
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Prazobind

Item No. 21409

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
[4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl]bicyclo[2.2.2]octa-2,5-dien-2-yl-methanone
CAS Number
107021-36-3
Synonyms
  • SZL-49
Molecular Formula
C23H27N5O3
Formula Weight
421.5
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 0.1mg/mL
λmax
212, 247, 331 nm
SMILES
COC(C(OC)=C1)=CC2=C1C(N)=NC(N3CCN(C(C4=CC5C=CC4CC5)=O)CC3)=N2
InChi Code
InChI=1S/C23H27N5O3/c1-30-19-12-17-18(13-20(19)31-2)25-23(26-21(17)24)28-9-7-27(8-10-28)22(29)16-11-14-3-5-15(16)6-4-14/h3,5,11-15H,4,6-10H2,1-2H3,(H2,24,25,26)
InChi Key
MXXRJJCMLRPJOF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Prazobind is an α1-adrenergic receptor (AR) antagonist.1 It inhibits binding of the α1-AR ligand, BE-2254, in rat hippocampus and liver, which highly express α1A- and α1B-ARs, respectively (IC50 = 1 nM for both).2 It decreases norepinephrine-induced contraction of isolated guinea pig aorta when used at a concentration of 1 nM.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Helman, J., Kusiak, J.W., Pitha, J., et al. Inhibition of α1-adrenergic responsiveness in intact cells by a new, irreversible receptor antagonist. Biochem. Bioph. Res. Commun. 142(2), 403-409 (1987).

    2. Mante, S., and Minneman, K.P. The alkylating prazosin analog SZL 49 inactivates both α1A- and α1B-adrenoceptors. Eur. J. Pharmacol. 208(2), 113-117 (1991).

    3. Oriowo, M. α1‐adrenoceptor subtype(s) mediating noradrenaline‐induced contractions of the guinea‐pig aorta. Fundam. Clin. Pharmacol. 8, 214-219 (1994).