A P2X2 and P2Y1 receptor agonist
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

2-Methylthioadenosine triphosphate (sodium salt)

Item No. 21418

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(methylthio)-adenosine 5'-(tetrahydrogen triphosphate), tetrasodium salt
CAS Number
100020-57-3
Synonyms
  • 2-methylthio ATP
  • 2-MeSATP
Molecular Formula
C11H14N5O13P3S • 4Na
Formula Weight
641.2
Purity
≥95%
Formulation (Request formulation change)
A 10 mM solution in water
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/mlWater: Soluble
λmax
234, 275 nm
SMILES
O[C@H]1[C@H](N2C=NC3=C2N=C(SC)N=C3N)O[C@H](COP(OP(OP([O-])([O-])=O)([O-])=O)([O-])=O)[C@H]1O.[Na+].[Na+].[Na+].[Na+]
InChi Code
InChI=1S/C11H18N5O13P3S.4Na/c1-33-11-14-8(12)5-9(15-11)16(3-13-5)10-7(18)6(17)4(27-10)2-26-31(22,23)29-32(24,25)28-30(19,20)21;;;;/h3-4,6-7,10,17-18H,2H2,1H3,(H,22,23)(H,24,25)(H2,12,14,15)(H2,19,20,21);;;;/q;4*+1/p-4/t4-,6-,7-,10-;;;;/m1..../s1
InChi Key
UEEFBRHXFDJPTA-KWIZKVQNSA-J
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    2.8 mg

    $116

    Add
    Product Description

    2-Methylthioadenosine triphosphate is an agonist of the purinergic P2X2 and P2Y1 receptors.1,2 It is also an inhibitor of guanylate cyclase C (GC-C) in rat intestinal mucosal membranes (Ki = 360 µM in the presence of E. coli heat-stable enterotoxin).3 2-Methylthioadenosine triphosphate (1 µM) induces calcium influx in primary rat arcuate nucleus neurons in a fluorescence-based reporter assay.1 It increases inositol phosphate accumulation in 1321N1 astrocytoma cells expressing human P2Y1 receptors (EC50 = 51 nM).2 2-Methylthioadenosine triphosphate inhibits uroguanylin-induced increases in urine flow and sodium excretion in rats.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Pollatzek, E., Hitzel, N., Ott, D., et al. Functional expression of P2 purinoceptors in a primary neuroglial cell culture of the rat arcuate nucleus. Neuroscience 327, 95-114 (2016).

    2. Schachter, J.B., and Harden, T.K. An examination of deoxyadenosine 5'(α-thio)triphosphate as a ligand to define P2Y receptors and its selectivity as a low potency partial agonist of the P2Y1 receptor. Br. J. Pharmacol. 121(2), 338-334 (1997).

    3. Parkinson, S.J., Carrithers, S.L., and Waldman, S.A. Opposing adenine nucleotide-dependent pathways regulate guanylyl cyclase C in rat intestine. The Journal of Biological Chemisty 269(36), 22683-22690 (1994).

    4. Zeng, C., Xia, T., Zheng, S., et al. Synergistic effect of uroguanylin and D1 dopamine receptors on sodium excretion in hypertension. J. Am. Heart Assoc. 11(6), e022827 (2022).