A sodium channel blocker
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(–)-Ropivacaine (hydrochloride hydrate)

Item No. 21422

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2S)-N-(2,6-dimethylphenyl)-1-propyl-2-piperidinecarboxamide, monohydrochloride, monohydrate
CAS Number
132112-35-7
Synonyms
  • LEA 103
  • (S)-Ropivacaine
Molecular Formula
C17H26N2O • HCl [H2O]
Formula Weight
328.9
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMSO: 25 mg/mlEthanol: 15 mg/mlPBS (pH 7.2): 0.25 mg/ml
SMILES
CC1=CC=CC(C)=C1NC([C@H]2N(CCC)CCCC2)=O.Cl.O
InChi Code
InChI=1S/C17H26N2O.ClH.H2O/c1-4-11-19-12-6-5-10-15(19)17(20)18-16-13(2)8-7-9-14(16)3;;/h7-9,15H,4-6,10-12H2,1-3H3,(H,18,20);1H;1H2/t15-;;/m0../s1
InChi Key
VSHFRHVKMYGBJL-CKUXDGONSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

    $70

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    50 mg

    $129

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    100 mg

    $242

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    250 mg

    $569

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    Product Description

    (–)-Ropivacaine is a potent and reversible blocker of sodium channels in nerve fibers.1 In vivo, (–)-ropivacaine induces complete impairment of proprioception, motor function, and nociception in the hindleg of rats when 100 μL of an 8 mM solution is injected percutaneously into the sciatic nerve.2 (–)-Ropivacaine depresses myocardial contractile force in isolated rat hearts less potently than (±)-ropivacaine, as well as (–)- and (±)-bupivacaine (Item No. 16618).3 Formulations containing (–)-ropivacaine have been used as local anesthetics during surgery and childbirth.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hansen, T.G. Ropivacaine: A pharmacological review. Exp. Rev. Neurother. 4(5), 781-791 (2004).

    2. Sinnott, C.J., and Strichartz, G.R. Levobupivacaine versus ropivacaine for sciatic nerve block in the rat. Reg. Anesth. Pain Med. 28(4), 294-303 (2003).

    3. Pinotti, M.F., Hepner, A., Campos, D.H., et al. Myocardial contractility impairment with racemic bupivacaine, non-racemic bupivacaine and ropivacaine. A comparative study. Acta Cir. Bras. 30(7), 484-490 (2015).