A selective inhibitor of PARP1
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BYK204165

Item No. 21430

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[(1-methyl-1H-pyrrol-2-yl)methylene]-1,3(2H,4H)-isoquinolinedione
CAS Number
1104546-89-5
Synonyms
  • PARP Inhibitor XIV
Molecular Formula
C15H12N2O2
Formula Weight
252.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/ml
λmax
427 nm
SMILES
O=C1NC(C(C=CC=C2)=C2/C1=C\C3=CC=CN3C)=O
InChi Code
InChI=1S/C15H12N2O2/c1-17-8-4-5-10(17)9-13-11-6-2-3-7-12(11)14(18)16-15(13)19/h2-9H,1H3,(H,16,18,19)/b13-9+
InChi Key
BTYSIDSTHDDAJW-UKTHLTGXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $41

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    5 mg

    $157

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    10 mg

    $215

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    25 mg

    $487

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    Cayman Chemical
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    Product Description

    BYK204165 is a selective inhibitor of poly(ADP-ribose) polymerase 1 (PARP1; IC50 = 44.67 nM for human recombinant PARP1 in an enzyme assay).1 It is selective for PARP1 over PARP2 (IC50 = 4,168 nM for murine PARP2 in an enzyme assay). BYK204165 inhibits hydrogen peroxide-activated PARP in A549 human lung epithelial, C4I human cervical, and H9c2 rat cardiac myoblast cells with IC50 values of 229.09, 1,778.28, and 123.03 nM, respectively.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Eltze, T., Boer, R., Wagner, T., et al. Imidazoquinolinone, imidazopyridine, and isoquinolindione derivatives as novel and potent inhibitors of the poly(ADP-ribose) polymerase (PARP): A comparison with standard PARP inhibitors. Mol. Pharmacol. 74(6), 1587-1598 (2008).