A prodrug form of quinaprilat
Related Products
Active Metabolite(s)
36007Quinaprilat
Labeled Version(s)
30735Quinapril-d5
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Quinapril (hydrochloride)

Item No. 21439

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid, monohydrochloride
CAS Number
82586-55-8
Synonyms
  • CI-906
  • PD 109452-2
Molecular Formula
C25H30N2O5 • HCl
Formula Weight
475.0
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 3.33 mg/ml
SMILES
O=C(OCC)[C@@H](N[C@@H](C)C(N1[C@H](C(O)=O)CC(C=CC=C2)=C2C1)=O)CCC3=CC=CC=C3.Cl
InChi Code
InChI=1S/C25H30N2O5.ClH/c1-3-32-25(31)21(14-13-18-9-5-4-6-10-18)26-17(2)23(28)27-16-20-12-8-7-11-19(20)15-22(27)24(29)30;/h4-12,17,21-22,26H,3,13-16H2,1-2H3,(H,29,30);1H/t17-,21-,22-;/m0./s1
InChi Key
IBBLRJGOOANPTQ-JKVLGAQCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    250 mg

    $129

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    500 mg

    $218

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    1 g

    $306

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    5 g

    $864

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    Product Description

    Quinapril is a prodrug form of the angiotensin converting enzyme (ACE) inhibitor quinaprilat.1,2 In vivo, quinapril (3 mg/kg) reduces mean arterial pressure in renal hypertensive and spontaneously hypertensive rats.2 It inhibits angiotensin I-induced pressor responses in normotensive rats and dogs. Quinapril (10-200 mg/kg) prevents left ventricular heart failure in CHF 14.6 cardiomyopathic hamsters. Formulations containing quinapril have been used in the treatment of hypertension, heart failure, and diabetic nephropathy.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Vago, T., Bevilacqua, M., Conci, F., et al. Angiotensin converting enzyme binding sites in human heart and lung: Comparison with rat tissues. Br. J. Pharmacol. 107(3), 821-825 (1992).

    2. Kaplan, H.R., Taylor, D.G., and Olson, S.C. Quinapril: Overview of preclinical data. Clin. Cardiol. 13(6 Suppl. 7), VII6-VII12 (1990).