A selective A1R agonist
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N6-Cyclopentyladenosine

Item No. 21448

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-cyclopentyl-adenosine
CAS Number
41552-82-3
Synonyms
  • CPA
  • UK 80882
Molecular Formula
C15H21N5O4
Formula Weight
335.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleEthanol: Warmed
SMILES
OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C=NC3=C(NC4CCCC4)N=CN=C32)O1
InChi Code
InChI=1S/C15H21N5O4/c21-5-9-11(22)12(23)15(24-9)20-7-18-10-13(16-6-17-14(10)20)19-8-3-1-2-4-8/h6-9,11-12,15,21-23H,1-5H2,(H,16,17,19)/t9-,11-,12-,15-/m1/s1
InChi Key
SQMWSBKSHWARHU-SDBHATRESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $36

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    50 mg

    $128

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    100 mg

    $186

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    Product Description

    N6-Cyclopentyladenosine is a selective agonist at adenosine 1 receptors (A1Rs) (Kis = 2.3, 790, and 43 nM for A1R, A2R, and A3R receptors, respectively, in transfected CHO cells).1,2 When microinjected into the rat brainstem, it increases blood pressure and heart rate.3 It is effective for pain in normal and nerve-injured rats and shows anticonvulsant activity in a rat model of generalized seizures.4,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Klotz, K.-N. Adenosine receptors and their ligands. Naunyn-Schmiedeberg's Arch. Pharmacol. 362(4), 382-391 (2000).

    2. Klotz, K.-N., Hessling, J., Hegler, J., et al. Comparative pharmacology of human adenosine receptor subtypes - characterization of stably transfected receptors in CHO cells. Naunyn-Schmiedeberg's Arch. Pharmacol. 357(1), 1-9 (1998).

    3. Barraco, R.A., el-Ridi, M.R., Ergene, E., et al. Adenosine receptor subtypes in the brainstem mediate distinct cardiovascular response patterns. Brain Res. Bull. 26(1), 59-84 (1991).

    4. Gong, Q.-J., Li, Y.-Y., Xin, W.-J., et al. Differential effects of adenosine A1 receptor on pain-related behavior in normal and nerve-injured rats. Brain Res. 1361, 23-30 (2010).

    5. Jaishree, J., Kumaresan, S., Sudha, S., et al. Individual and combined effects of N6-cyclopentyladenosine, flunarizine and diazepam on aminophylline-induced recurrent generalized seizures in mice. Pol. J. Pharmacol. 55(4), 559-564 (2003).