A potent, selective, and neutral inhibitor of cathepsin K
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Odanacatib

Item No. 21466

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2S)-N-(1-cyanocyclopropyl)-4-fluoro-4-methyl-2-[[(1S)-2,2,2-trifluoro-1-[4'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]ethyl]amino]-pentanamide
CAS Number
603139-19-1
Synonyms
  • MK-0822
Molecular Formula
C25H27F4N3O3S
Formula Weight
525.6
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH 7.2)(1:3): 0.25 mg/mlDMSO: 15 mg/ml
λmax
265 nm
SMILES
CS(C(C=C1)=CC=C1C2=CC=C([C@@H](C(F)(F)F)N([H])[C@H](C(N([H])C3(CC3)C#N)=O)CC(F)(C)C)C=C2)(=O)=O
InChi Code
InChI=1S/C25H27F4N3O3S/c1-23(2,26)14-20(22(33)32-24(15-30)12-13-24)31-21(25(27,28)29)18-6-4-16(5-7-18)17-8-10-19(11-9-17)36(3,34)35/h4-11,20-21,31H,12-14H2,1-3H3,(H,32,33)/t20-,21-/m0/s1
InChi Key
FWIVDMJALNEADT-SFTDATJTSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $63

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    5 mg

    $257

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    10 mg

    $481

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    25 mg

    $1,053

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    Product Description

    Odanacatib is a potent, selective, and neutral inhibitor of cathepsin K (IC50s = 0.2 and 1 nM for human and rabbit enzymes, respectively), a protease involved in osteoclastic bone resorption.1 It demonstrates high selectivity for cathepsin K over cathepsins B, L, and S. Formulations containing odanacatib reduce bone resorption, with lesser reductions in bone formation, resulting in increased bone mineral density.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gauthier, J.Y., Chauret, N., Cromlish, W., et al. The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K. Bioor. Med. Chem. Lett. 18(3), 923-928 (2008).

    2. Chapurlat, R.D. Odanacatib: A review of its potential in the management of osteoporosis in postmenopausal women. Ther. Adv. Musculoskelet. Dis. 7(3), 103-109 (2015).

    3. Rachner, T.D., Khosla, S., and Hofbauer, L.C. New horizons in osteoporosis. Lancet. 377(9773), 1276-1298 (2011).