A fluorescent probe for lipid peroxides
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Liperfluo

Item No. 21467

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[4-(diphenylphosphino)phenyl]-9-(3,6,9,12-tetraoxatridec-1-yl)-anthra[2,1,9-def:6,5,10-d’e’f′]diisoquinoline-1,3,8,10(2H,9H)-tetrone
CAS Number
1448846-35-2
Molecular Formula
C51H41N2O8P
Formula Weight
840.9
Purity
≥90%
Emission
500-550 nm
Excitation
488 nm
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
SMILES
O=C(C(C=C1)=C2C3=C1C4=CC=C(C(N5CCOCCOCCOCCOC)=O)C(C4=C(C3=CC=C26)C=C7)=C7C5=O)N(C8=CC=C(P(C9=CC=CC=C9)C%10=CC=CC=C%10)C=C8)C6=O
InChi Code
InChI=1S/C51H41N2O8P/c1-58-26-27-60-30-31-61-29-28-59-25-24-52-48(54)40-20-16-36-38-18-22-42-47-43(23-19-39(45(38)47)37-17-21-41(49(52)55)46(40)44(36)37)51(57)53(50(42)56)32-12-14-35(15-13-32)62(33-8-4-2-5-9-33)34-10-6-3-7-11-34/h2-23H,24-31H2,1H3
InChi Key
MDGOURRQWXHVBZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
4°C
Shipping
Wet ice in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    5 x 50 µg

    $347

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    Product Description

    Liperfluo is a fluorescent probe for lipid peroxides.1,2 Upon reaction with lipid peroxides, Liperfluo is oxidized and displays an emission maximum of 500-550 nm upon excitation at 488 nm.1 It is selective for lipid peroxides over hydrogen peroxide, hydroxyl radical, superoxide, nitric oxide, peroxynitrite, alkylperoxyl radical, and cumene hydroperoxide. Monitoring lipid peroxidation has high relevance to various cellular processes, especially ferroptosis, which is an iron-dependent cell death characterized by increased lipid peroxidation.3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yamanaka, K., Saito, Y., Sakiyama, J., et al. A novel fluorescent probe with high sensitivity and selective detection of lipid hydroperoxides in cells. RSC Adv. 20, 7894-7900 (2012).

    2. Kagan, V.E., Mao, G., Qu, F., et al. Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis. Nat. Chem. Biol. 13(1), 81-90 (2017).

    3. Angeli, J.P.F., Miyamoto, S., and Schulze, A. Ferroptosis: The greasy side of cell death. Chem. Res. Toxicol. 32, 362-369 (2019).

    4. Yang, W.S., and Stockwell, B.R. Ferroptosis: Death by lipid peroxidation. Trends Cell Biol. 26(3), 165-176 (2016).