VK₃-OCH₃

VK₃-OCH₃ is an analog of vitamin K₃ (Item No. 15950) that that has antiproliferative activities in vitro.¹ It preferentially decreases proliferation of IMR-32, LA-N-1, NB-39, and SK-N-SH neuroblastoma cells (IC₅₀s = 2.43, 1.55, 10.69, and 3.45 µM, respectively) compared with non-cancerous HUVEC and HDF cells (IC₅₀s = 26.24 and 87.11 µM, respectively). It increases heme oxygenase-1 (HO-1) and caveolin-1 levels, induces apoptosis, and halts the cell cycle at the G₂/M phase in IMR-32 cells. VK₃-OCH₃ also inhibits protein-tyrosine phosphorylase (PTPase) activity (IC₅₀ = 57.2 µM in a cell-free assay), induces protein-tyrosine phosphorylation in Hep3B hepatoma cells when used at a concentration of 50 µM, and inhibits the growth of Hep3B cells (IC₅₀ = 8.6 µM).²

WARNING This product is not for human or veterinary use.

1. Kitano, T., Yoda, H., Tabata, K., et al. Vitamin K₃ analogs induce selective tumor cytotoxicity in neuroblastoma. Biol. Pharm. Bull. 35(4), 617-623 (2012).

2. Nishikawa, Y., Wang, Z., Kerns, J., et al. Inhibition of hepatoma cell growth in vitro by arylating and non-arylating K vitamin analogs. Significance of protein tyrosine phosphatase inhibition. The Journal of Biological Chemisty 274(49), 34803-34810 (1999).