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WEHI-539

Item № 21478
CAS № 1431866-33-9
Purity ≥98%
product image
                (CAS 1431866-33-9)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     1 mg $45.00 0.00
     5 mg $191.00 0.00
     10 mg $338.00 0.00

Pricing updated 2019-07-17. Prices are subject to change without notice.

Description

WEHI-539 is an inhibitor of Bcl-xL (IC50 = 1.1 nM) that demonstrates more than 400-fold selectivity for Bcl-xL over Bcl-2, Mcl-1, Bcl-W, or A1.1 It has been shown to induce apoptosis specifically in Mcl-1 deficient cells and does not affect Bcl-2 overexpressing cells.1 WEHI-539 can be used as a tool for distinguishing the roles of Bcl-xL in both normal and cancer cells from those of the related prosurvival proteins such as Bcl-2 and Mcl-1.1

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Technical Information
Formal Name
5-[3-[4-(aminomethyl)phenoxy]propyl]-2-[8-[2-(2-benzothiazolyl)hydrazinylidene]-5,6,7,8-tetrahydro-2-naphthalenyl]-4-thiazolecarboxylic acid
CAS Number
1431866-33-9
Molecular Formula
C31H29N5O3S2
Formula Weight
583.7
Purity
≥98%
Formulation
A crystalline solid
λmax
224, 252, 306, 335 nm
SMILES
[H]N(/N=C1C(C=C(C2=NC(C(O)=O)=C(CCCOC3=CC=C(CN)C=C3)S2)C=C4)=C4CCC/1)C5=NC6=CC=CC=C6S5
InChI Code
InChI=1S/C31H29N5O3S2/c32-18-19-10-14-22(15-11-19)39-16-4-9-27-28(30(37)38)34-29(40-27)21-13-12-20-5-3-7-24(23(20)17-21)35-36-31-33-25-6-1-2-8-26(25)41-31/h1-2,6,8,10-15,17H,3-5,7,9,16,18,32H2,(H,33,36)(H,37,38)/b35-24+
InChI Key
JKMWZKPAXZBYEH-JWHWKPFMSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 2 years
Downloads & Resources
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Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

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References & Product Citations
Product Description References

1. Lessene, G., Czabotar, P.E., Sleebs, B.E., et al. Structure-guided design of a selective BCL-XL inhibitor ACS Med. Chem. Lett. 5(6), 662-667 (2014).

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