A reversible elastase inhibitor
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Elasnin

Item No. 21481

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,5-dibutyl-6-(1-butyl-2-oxoheptyl)-4-hydroxy-2H-pyran-2-one
CAS Number
68112-21-0
Molecular Formula
C24H40O4
Formula Weight
392.6
Purity
≥95%
Formulation
A liquid
Solubility(Learn about Variance in Solubility)
Dichloromethane: solubleDMSO: 5 mg/mlMethanol: 5 mg/ml
SMILES
O=C1OC(C(CCCC)C(CCCCC)=O)=C(CCCC)C(O)=C1CCCC
InChi Code
InChI=1S/C24H40O4/c1-5-9-13-17-21(25)18(14-10-6-2)23-19(15-11-7-3)22(26)20(16-12-8-4)24(27)28-23/h18,26H,5-17H2,1-4H3
InChi Key
SNSPVFCYLPZTRZ-UHFFFAOYSA-N
Origin
Bacterium/Streptomyces sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $422

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    Product Description

    Elasnin is a product isolated from certain strains of Streptomyces that acts as a reversible inhibitor of elastase with IC50 values of 1.3 and 30 µg/ml for human granulocyte and pancreatic enzymes, respectively.1 It inhibits human leukocyte elastase, porcine pancreatic elastase, and chymotrypsin with Ki values of 93, 69, and 224 µM, respectively.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ohno, H., Saheki, T., Awaya, J., et al. Isolation and characterization of elasnin, a new human granulocyte elastase inhibitor produced by a strain of Streptomyces. J. Antibiot. (Tokyo) 31(11), 1116-1123 (1978).

    2. Spencer, R.W., Copp, L.J., and Pfister, J.R. Inhibition of human leukocyte elastase, porcine pancreatic elastase, and chymotrypsin by elasnin and other 4-hydroxy-2-pyrones. J. Med. Chem. 28(12), 1828-1832 (1985).