A glucosylceramide synthase inhibitor
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Labeled Version(s)
30167Eliglustat-d15 (tartrate)
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Eliglustat (hemitartrate)

Item No. 21487

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(1R,2R)-2-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-hydroxy-1-(1-pyrrolidinylmethyl)ethyl]-octanamide, 2R,3R-dihydroxybutanedioate (2:1)
CAS Number
928659-70-5
Synonyms
  • Genz-112638
Molecular Formula
C23H36N2O4 • 1/2C4H6O6
Formula Weight
479.6
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlEthanol: 20 mg/mlEthanol:PBS (pH 7.2) (1:30): 0.03 mg/ml
λmax
286 nm
SMILES
O[C@@H]([C@H](N([H])C(CCCCCCC)=O)CN1CCCC1)C2=CC=C(OCCO3)C3=C2.OC([C@H](O)[C@@H](O)C(O)=O)=O.O[C@@H]([C@H](N([H])C(CCCCCCC)=O)CN4CCCC4)C5=CC=C(OCCO6)C6=C5
InChi Code
InChI=1S/2C23H36N2O4.C4H6O6/c2*1-2-3-4-5-6-9-22(26)24-19(17-25-12-7-8-13-25)23(27)18-10-11-20-21(16-18)29-15-14-28-20;5-1(3(7)8)2(6)4(9)10/h2*10-11,16,19,23,27H,2-9,12-15,17H2,1H3,(H,24,26);1-2,5-6H,(H,7,8)(H,9,10)/t2*19-,23-;1-,2-/m111/s1
InChi Key
KUBARPMUNHKBIQ-VTHUDJRQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $29

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    5 mg

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    10 mg

    $101

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    25 mg

    $143

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    Product Description

    Eliglustat is an inhibitor of glucosylceramide synthase (IC50 = 40 nM for inhibition of glucosylceramide production in K562 cells).1 It is selective for glucosylceramide synthase over α-glucosidase I and II, α-1,6-glucosidase, lysosomal glucocerebrosidase, non-lysosomal glucosylceramidase, sucrase, and maltase (IC50s = >10 µM for all). It decreases cell surface levels of the gangliosides GM1 and GM3 in K562 and B16/F10 cells with IC50 values of 24 and 29 nM, respectively. Eliglustat (150 mg/kg per day) decreases glucosylceramide levels in the liver and lungs of D409V/null mice, a model of Gaucher disease. Formulations containing eliglustat have been used in the treatment of type 1 Gaucher disease.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. McEachern, K.A., Fung, J., Komarnitsky, S., et al. A specific and potent inhibitor of glucosylceramide synthase for substrate inhibition therapy of Gaucher disease. Mol. Genet. Metab. 91(3), 259-267 (2007).